Contents 1 Hypothesis 2 Implications 3 See also 4 References 5 Further reading

Hypothesis[edit] Like viruses,[which?] a eukaryotic nucleus contains linear chromosomes with specialized end sequences (in contrast to bacterial genomes, which have a circular topology); it uses mRNA capping, and separates transcription from translation. Eukaryotic nuclei are also capable of cytoplasmic replication. Some large viruses have their own DNA-directed RNA polymerase.[4] Transfers of "infectious" nuclei have been documented in many parasitic red algae.[5] The viral eukaryogenesis hypothesis posits that eukaryotes are composed of three ancestral elements: a viral component that became the modern nucleus; a prokaryotic cell (originally thought to be very primitive but more probably an archaeon according to Eocyte hypothesis) that donated the cytoplasm and cell membrane of modern cells; and another prokaryotic (bacterial) cell that, by endocytosis, became the modern mitochondrion or chloroplast. Molecular homology suggests that all life shares a single common ancestor, and evidence, alongside the fossil record, can be found in the evolution of prokaryotes, and Archaea prior to the eukaryotes. The viral eukaryogenesis hypothesis points to the cell cycle of eukaryotes, particularly sex and meiosis, as evidence.[6] Little is known about DNA or the origins of reproduction in prokaryotic or eukaryotic cells. It is thus possible that viruses were involved in the creation of Earth's first cells.[7] In 2006, researchers suggested that the transition from RNA to DNA genomes first occurred in the viral world.[8] A DNA-based virus may have provided storage for an ancient host that had previously used RNA to store its genetic information (such host is called ribocell or ribocyte).[4] Viruses may initially have adopted DNA as a way to resist RNA-degrading enzymes in the host cells. Hence, the contribution from such a new component may have been as significant as the contribution from chloroplasts or mitochondria. Following this hypothesis, archaea, Bacteria, and eukaryotes each obtained their DNA informational system from a different virus.[8] In the original paper it was also an RNA cell at the origin of eukaryotes, but eventually more complex, featuring RNA processing. Although this is in contrast to nowadays more probable Eocyte hypothesis, viruses seem to have contributed to the origin of all three domains of life ('out of virus hypothesis'). It has also been suggested that telomerase and telomeres, key aspects of eukaryotic cell replication, have viral origins. Further, the viral origins of the modern eukaryotic nucleus may have relied on multiple infections of archaeal cells carrying bacterial mitochondrial precursors with lysogenic viruses.[9] The viral eukaryogenesis hypothesis depicts a model of eukaryotic evolution in which a virus, similar to a modern pox virus, evolved into a nucleus via gene acquisition from existing bacterial and archaeal species. The lysogenic virus then became the information storage center for the cell, while the cell retained its capacities for gene translation and general function despite the viral genome's entry. Similarly, the bacterial species involved in this eukaryogenesis retained its capacity to produce energy in the form of ATP while also passing much of its genetic information into this new virus-nucleus organelle. It is hypothesized that the modern cell cycle, whereby mitosis, meiosis, and sex occur in all eukaryotes, evolved because of the balances struck by viruses, which characteristically follow a pattern of tradeoff between infecting as many hosts as possible and killing an individual host through viral proliferation. Hypothetically, viral replication cycles may mirror those of plasmids and viral lysogens. However, this theory is controversial, and additional experimentation involving archaeal viruses is necessary, as they are probably the most evolutionarily similar to modern eukaryotic nuclei.[6]

Implications[edit] A number of precepts in the theory are possible. For instance, a helical virus with a bilipid envelope bears a distinct resemblance to a highly simplified cellular nucleus (i.e., a DNA chromosome encapsulated within a lipid membrane). In theory, a large DNA virus could take control of a bacterial or archaeal cell. Instead of replicating and destroying the host cell, it would remain within the cell, thus overcoming the tradeoff dilemma typically faced by viruses. With the virus in control of the host cell's molecular machinery, it would effectively become a functional nucleus. Through the processes of mitosis and cytokinesis, the virus would thus recruit the entire cell as a symbiont—a new way to survive and proliferate. The similarities between DNA viruses and nuclei can be taken as evidence either of viral eukaryogensis or of its converse, nuclear viriogenesis: that complex eukaryotic DNA viruses could have originated from infectious nuclei.[4]

See also[edit] Endogenous retrovirus Endogenous viral element Paleovirology

References[edit] ^ Philip John Livingstone Bell (2001). "Viral eukaryogenesis: Was the ancestor of the nucleus a complex DNA virus?". Journal of Molecular Evolution. 53 (3): 251–256. doi:10.1007/s002390010215. PMID 11523012.  ^ Chaikeeratisak, V; Nguyen, K; Khanna, K; Brilot, AF; Erb, ML; Coker, JKC; Vavilina, A; Newton, GL; Buschauer, R; Pogliano, K; Villa, E; Agard, DA; Pogliano, J (2017). "Assembly of a nucleus-like structure during viral replication in bacteria". Science. 355 (6321): 194–197. doi:10.1126/science.aal2130. PMID 28082593.  ^ Chaikeeratisak, V; Nguyen, K; Egan, ME; Erb, ML; Vavilina, A; Pogliano, J (2017). "The Phage Nucleus and Tubulin Spindle Are Conserved among Large Pseudomonas Phages". Cell Reports. 20 (7): 1563–1571. doi:10.1016/j.celrep.2017.07.064. PMID 28813669.  ^ a b c d Claverie, Jean-Michel (2006). "Viruses take center stage in cellular evolution". Genome Biology. 7 (6): 110. doi:10.1186/gb-2006-7-6-110. PMC 1779534 . PMID 16787527.  ^ Goff, Lynda J.; Coleman, Annette W. (1995). "Fate of Parasite and Host Organelle DNA during Cellular Transformation of Red Algae by Their Parasites". The Plant Cell Online. 7 (11): 1899–1911. doi:10.1105/tpc.7.11.1899. JSTOR 3870197. PMC 161048 . PMID 12242362.  ^ a b Philip John Livingstone Bell (2006). "Sex and the eukaryotic cell cycle is consistent with a viral ancestry for the eukaryotic nucleus". Journal of Theoretical Biology. 243 (1): 54–63. doi:10.1016/jjtbi200605015.  ^ Trevors, Jack Thomas (2003). "Genetic material in the early evolution of bacteria". Microbiological Research. 158 (11): 1–6. doi:10.1078/0944-5013-00171.  ^ a b Forterre, Patrick (2006). "Three RNA cells for ribosomal lineages and three DNA viruses to replicate their genomes: A hypothesis for the origin of cellular domain". Proceedings of the National Academy of Sciences. 103 (10): 3669–74. Bibcode:2006PNAS..103.3669F. doi:10.1073/pnas.0510333103. JSTOR 30048645. PMC 1450140 . PMID 16505372.  ^ Witzany, Guenther (2008). "The viral origins of telomeres and telomerases and their important role in eukaryogenesis and genome maintenance" (PDF). Biosemiotics. 1: 191–206. doi:10.1007/s12304-008-9018-0. 

Further reading[edit] Livingstone Bell, Philip John (2001). "Viral Eukaryogenesis: was the ancestor of the nucleus a complex DNA virus?". Journal of Molecular Evolution. 53 (3): 251–6. doi:10.1007/s002390010215. PMID 11523012.  Trevors, Jack Thomas (2003). "Genetic material in the early evolution of bacteria". Microbiological Research. 158 (11): 1–6. doi:10.1078/0944-5013-00171.  Retrieved from "" Categories: MicrobiologyEvolutionary biologyVirologySymbiosisCell nucleusEukaryote biologyHidden categories: All Wikipedia articles needing clarificationWikipedia articles needing clarification from November 2015All articles with specifically marked weasel-worded phrasesArticles with specifically marked weasel-worded phrases from December 2017

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