Contents 1 Function 2 Clinical significance 3 Diagnostic utility 4 Interactions 5 Regulation 6 See also 7 References 8 Further reading 9 External links


Function[edit] Tumor protein p63 is a member of the p53 family of transcription factors. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. TP63 encodes for two main isoforms by alternative promoters (TAp63 and ΔNp63). ΔNp63 is involved in multiple functions during skin development and in adult stem/progenitor cell regulation.[11] In contrast, TAp63 has been mostly restricted to its apoptotic function and more recently as the guardian of oocyte integrity.[12] Recently, two new functions have been attributed to TAp63 in heart development[13] and premature aging.[14]


Clinical significance[edit] TP63 mutations underlie several malformation syndromes that include cleft lip and/or palate as a hallmark feature.[15] Mutations in the TP63 gene are associated with ectrodactyly-ectodermal dysplasia-cleft syndrome in which a midline cleft lip is a common feature,[15] cleft lip/palate syndrome 3 (EEC3); ectrodactyly (also known as split-hand/foot malformation 4 (SHFM4)); ankyloblepharon-ectodermal dysplasia-cleft lip/palate (AEC) or Hay–Wells syndrome in which a midline cleft lip is also a common feature,[15] Acro–dermato–ungual–lacrimal–tooth syndrome (ADULT); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both cleft lip with or without a cleft palate and cleft palate only features have been seen to segregate within the same family with a TP63 mutation.[15] Recently, induced pluripotent stem cells have been produced from patients affected by EEC syndromes by cell reprogramming. The defective epithelial commitment could be partially rescued by a small therapeutic compound.[16]


Diagnostic utility[edit] p63 immunostaining has utility for head and neck squamous cell carcinomas, differentiating prostatic adenocarcinoma (the most common type of prostate cancer) and benign prostatic tissue;[17] normal prostatic glands stain with p63 (as they have basal cells), while the malignant glands in prostatic adenocarcinoma (which lacks these cells) do not.[18] P63 is also helpful in distinguishing poorly differentiated squamous cell carcinoma from small cell carcinoma or adenocarcinoma. P63 should be strongly stained in poorly differentiated squamous cell, but negative in small cell or adenocarcinoma.[19]


Interactions[edit] TP63 has been shown to interact with HNRPAB.[20] It also activates IRF6 transcription through the IRF6 enhancer element.[15]


Regulation[edit] There is some evidence that the expression of p63 is regulated by the microRNA miR-203.[21][22]


See also[edit] AMACR - another marker for prostate adenocarcinoma


References[edit] ^ a b c GRCh38: Ensembl release 89: ENSG00000073282 - Ensembl, May 2017 ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022510 - Ensembl, May 2017 ^ "Human PubMed Reference:".  ^ "Mouse PubMed Reference:".  ^ Yang A, Kaghad M, Wang Y, Gillett E, Fleming MD, Dötsch V, Andrews NC, Caput D, McKeon F (Sep 1998). "p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities". Molecular Cell. 2 (3): 305–16. doi:10.1016/S1097-2765(00)80275-0. PMID 9774969.  ^ Osada M, Ohba M, Kawahara C, Ishioka C, Kanamaru R, Katoh I, Ikawa Y, Nimura Y, Nakagawara A, Obinata M, Ikawa S (Jul 1998). "Cloning and functional analysis of human p51, which structurally and functionally resembles p53". Nature Medicine. 4 (7): 839–43. doi:10.1038/nm0798-839. PMID 9662378.  ^ Zeng X, Zhu Y, Lu H (Feb 2001). "NBP is the p53 homolog p63". Carcinogenesis. 22 (2): 215–9. doi:10.1093/carcin/22.2.215. PMID 11181441.  ^ Tan M, Bian J, Guan K, Sun Y (Feb 2001). "p53CP is p51/p63, the third member of the p53 gene family: partial purification and characterization". Carcinogenesis. 22 (2): 295–300. doi:10.1093/carcin/22.2.295. PMID 11181451.  ^ Wu G, Nomoto S, Hoque MO, Dracheva T, Osada M, Lee CC, Dong SM, Guo Z, Benoit N, Cohen Y, Rechthand P, Califano J, Moon CS, Ratovitski E, Jen J, Sidransky D, Trink B (May 2003). "DeltaNp63alpha and TAp63alpha regulate transcription of genes with distinct biological functions in cancer and development". Cancer Research. 63 (10): 2351–7. PMID 12750249.  ^ Skipper M (January 2007). "Dedicated protection for the female germline". Nature Reviews Molecular Cell Biology. 8 (1): 4–5. doi:10.1038/nrm2091.  ^ Crum CP, McKeon FD (2010). "p63 in epithelial survival, germ cell surveillance, and neoplasia". Annual Review of Pathology. 5: 349–71. doi:10.1146/annurev-pathol-121808-102117. PMID 20078223.  ^ Deutsch GB, Zielonka EM, Coutandin D, Weber TA, Schäfer B, Hannewald J, Luh LM, Durst FG, Ibrahim M, Hoffmann J, Niesen FH, Sentürk A, Kunkel H, Brutschy B, Schleiff E, Knapp S, Acker-Palmer A, Grez M, McKeon F, Dötsch V (Feb 2011). "DNA damage in oocytes induces a switch of the quality control factor TAp63α from dimer to tetramer". Cell. 144 (4): 566–76. doi:10.1016/j.cell.2011.01.013. PMC 3087504 . PMID 21335238.  ^ Rouleau M, Medawar A, Hamon L, Shivtiel S, Wolchinsky Z, Zhou H, De Rosa L, Candi E, de la Forest Divonne S, Mikkola ML, van Bokhoven H, Missero C, Melino G, Pucéat M, Aberdam D (Nov 2011). "TAp63 is important for cardiac differentiation of embryonic stem cells and heart development". Stem Cells. 29 (11): 1672–83. doi:10.1002/stem.723. PMID 21898690.  ^ Su X, Paris M, Gi YJ, Tsai KY, Cho MS, Lin YL, Biernaskie JA, Sinha S, Prives C, Pevny LH, Miller FD, Flores ER (Jul 2009). "TAp63 prevents premature aging by promoting adult stem cell maintenance". Cell Stem Cell. 5 (1): 64–75. doi:10.1016/j.stem.2009.04.003. PMC 3418222 . PMID 19570515.  ^ a b c d e Dixon MJ, Marazita ML, Beaty TH, Murray JC (Mar 2011). "Cleft lip and palate: understanding genetic and environmental influences". Nature Reviews Genetics. 12 (3): 167–78. doi:10.1038/nrg2933. PMC 3086810 . PMID 21331089.  ^ Shalom Feuerstein R. et al. Impaired epithelial differentiation of induced pluripotent stem cells from EEC patients is rescued by APR-246/PRIMA-1MET. P.N.A.S 2012. http://minus.com/lbmC3TVGDx350s ^ Shiran MS, Tan GC, Sabariah AR, Rampal L, Phang KS (Mar 2007). "p63 as a complimentary basal cell specific marker to high molecular weight-cytokeratin in distinguishing prostatic carcinoma from benign prostatic lesions". The Medical Journal of Malaysia. 62 (1): 36–9. PMID 17682568.  ^ Herawi M, Epstein JI (Jun 2007). "Immunohistochemical antibody cocktail staining (p63/HMWCK/AMACR) of ductal adenocarcinoma and Gleason pattern 4 cribriform and noncribriform acinar adenocarcinomas of the prostate". The American Journal of Surgical Pathology. 31 (6): 889–94. doi:10.1097/01.pas.0000213447.16526.7f. PMID 17527076.  ^ Zhang H, Liu J, Cagle PT, Allen TC, Laga AC, Zander DS (Jan 2005). "Distinction of pulmonary small cell carcinoma from poorly differentiated squamous cell carcinoma: an immunohistochemical approach". Modern Pathology. 18 (1): 111–8. doi:10.1038/modpathol.3800251. PMID 15309021.  ^ Fomenkov A, Huang YP, Topaloglu O, Brechman A, Osada M, Fomenkova T, Yuriditsky E, Trink B, Sidransky D, Ratovitski E (Jun 2003). "P63 alpha mutations lead to aberrant splicing of keratinocyte growth factor receptor in the Hay-Wells syndrome". The Journal of Biological Chemistry. 278 (26): 23906–14. doi:10.1074/jbc.M300746200. PMID 12692135.  ^ Yi R, Poy MN, Stoffel M, Fuchs E (Mar 2008). "A skin microRNA promotes differentiation by repressing 'stemness'". Nature. 452 (7184): 225–9. doi:10.1038/nature06642. PMID 18311128.  ^ Aberdam D, Candi E, Knight RA, Melino G (Dec 2008). "miRNAs, 'stemness' and skin". Trends in Biochemical Sciences. 33 (12): 583–91. doi:10.1016/j.tibs.2008.09.002. PMID 18848452. 


Further reading[edit] Little NA, Jochemsen AG (Jan 2002). "p63". The International Journal of Biochemistry & Cell Biology. 34 (1): 6–9. doi:10.1016/S1357-2725(01)00086-3. PMID 11733180.  van Bokhoven H, McKeon F (Mar 2002). "Mutations in the p53 homolog p63: allele-specific developmental syndromes in humans". Trends in Molecular Medicine. 8 (3): 133–9. doi:10.1016/S1471-4914(01)02260-2. PMID 11879774.  van Bokhoven H, Brunner HG (Jul 2002). "Splitting p63". American Journal of Human Genetics. 71 (1): 1–13. doi:10.1086/341450. PMC 384966 . PMID 12037717.  Brunner HG, Hamel BC, van Bokhoven H (Oct 2002). "P63 gene mutations and human developmental syndromes". American Journal of Medical Genetics. 112 (3): 284–90. doi:10.1002/ajmg.10778. PMID 12357472.  Jacobs WB, Walsh GS, Miller FD (Oct 2004). "Neuronal survival and p73/p63/p53: a family affair". The Neuroscientist. 10 (5): 443–55. doi:10.1177/1073858404263456. PMID 15359011.  Zusman I (2005). "The soluble p51 protein in cancer diagnosis, prevention and therapy". In Vivo. 19 (3): 591–8. PMID 15875781.  Morasso MI, Radoja N (Sep 2005). "Dlx genes, p63, and ectodermal dysplasias". Birth Defects Research. Part C, Embryo Today. 75 (3): 163–71. doi:10.1002/bdrc.20047. PMC 1317295 . PMID 16187309.  Barbieri CE, Pietenpol JA (Apr 2006). "p63 and epithelial biology". Experimental Cell Research. 312 (6): 695–706. doi:10.1016/j.yexcr.2005.11.028. PMID 16406339.  Shalom-Feuerstein R, Lena AM, Zhou H, De La Forest Divonne S, Van Bokhoven H, Candi E, Melino G, Aberdam D (May 2011). "ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis". Cell Death and Differentiation. 18 (5): 887–96. doi:10.1038/cdd.2010.159. PMC 3131930 . PMID 21127502. 


External links[edit] TP73L protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) GeneReviews/NCBI/NIH/UW entry on Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate Syndrome or AEC Syndrome, Hay-Wells Syndrome. Includes: Rapp-Hodgkin Syndrome OMIM entries on AEC TP63 human gene location in the UCSC Genome Browser. TP63 human gene details in the UCSC Genome Browser. v t e PDB gallery 1rg6: Solution structure of the C-terminal domain of p63  v t e Neoplasm: Tumor suppressor genes/proteins and Oncogenes/Proto-oncogenes Ligand Growth factors ONCO c-Sis/PDGF HGF Receptor Wnt signaling pathway TSP CDH1 Hedgehog signaling pathway TSP PTCH1 TGF beta signaling pathway TSP TGF beta receptor 2 Receptor tyrosine kinase ONCO ErbB/c-ErbB HER2/neu Her 3 c-Met c-Ret JAK-STAT signaling pathway ONCO c-Kit Flt3 Intracellular signaling P+Ps Wnt signaling pathway ONCO Beta-catenin TSP APC TGF beta signaling pathway TSP SMAD2 SMAD4 Akt/PKB signaling pathway ONCO c-Akt TSP PTEN Hippo signaling pathway TSP Neurofibromin 2/Merlin MAPK/ERK pathway ONCO c-Ras HRAS c-Raf TSP Neurofibromin 1 Other/unknown ONCO c-Src TSP Maspin Nucleus Cell cycle ONCO CDK4 Cyclin D Cyclin E TSP p53 pRb WT1 p16/p14arf DNA repair/Fanconi TSP BRCA1 BRCA2 Ubiquitin ligase ONCO CBL MDM2 TSP VHL Transcription factor ONCO AP-1 c-Fos c-Jun c-Myc TSP KLF6 Mitochondrion Apoptosis inhibitor SDHB SDHD Other/ungrouped c-Bcl-2 Notch Stathmin v t e Transcription factors and intracellular receptors (1) Basic domains (1.1) Basic leucine zipper (bZIP) Activating transcription factor AATF 1 2 3 4 5 6 7 AP-1 c-Fos FOSB FOSL1 FOSL2 JDP2 c-Jun JUNB JunD BACH 1 2 BATF BLZF1 C/EBP α β γ δ ε ζ CREB 1 3 L1 CREM DBP DDIT3 GABPA GCN4 HLF MAF B F G K NFE 2 L1 L2 L3 NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix-loop-helix (bHLH) ATOH1 AhR AHRR ARNT ASCL1 BHLH 2 3 9 ARNTL ARNTL ARNTL2 CLOCK EPAS1 FIGLA HAND 1 2 HES 5 6 HEY 1 2 L HES1 HIF 1A 3A ID 1 2 3 4 LYL1 MESP2 MXD4 MYCL1 MYCN Myogenic regulatory factors MyoD Myogenin MYF5 MYF6 Neurogenins 1 2 3 NeuroD 1 2 NPAS 1 2 3 OLIG 1 2 Pho4 Scleraxis SIM 1 2 TAL 1 2 Twist USF1 (1.3) bHLH-ZIP AP-4 MAX MXD3 MITF MNT MLX MXI1 Myc SREBP 1 2 (1.4) NF-1 NFI A B C X SMAD R-SMAD 1 2 3 5 9 I-SMAD 6 7 4) (1.5) RF-X RFX 1 2 3 4 5 6 ANK (1.6) Basic helix-span-helix (bHSH) AP-2 α β γ δ ε (2) Zinc finger DNA-binding domains (2.1) Nuclear receptor (Cys4) subfamily 1 Thyroid hormone α β CAR FXR LXR α β PPAR α β/δ γ PXR RAR α β γ ROR α β γ Rev-ErbA α β VDR subfamily 2 COUP-TF (I II Ear-2 HNF4 α γ PNR RXR α β γ Testicular receptor 2 4 TLX subfamily 3 Steroid hormone Androgen Estrogen α β Glucocorticoid Mineralocorticoid Progesterone Estrogen related α β γ subfamily 4 NUR NGFIB NOR1 NURR1 subfamily 5 LRH-1 SF1 subfamily 6 GCNF subfamily 0 DAX1 SHP (2.2) Other Cys4 GATA 1 2 3 4 5 6 MTA 1 2 3 TRPS1 (2.3) Cys2His2 General transcription factors TFIIA TFIIB TFIID TFIIE 1 2 TFIIF 1 2 TFIIH 1 2 4 2I 3A 3C1 3C2 ATBF1 BCL 6 11A 11B CTCF E4F1 EGR 1 2 3 4 ERV3 GFI1 GLI-Krüppel family 1 2 3 REST S1 S2 YY1 HIC 1 2 HIVEP 1 2 3 IKZF 1 2 3 ILF 2 3 KLF 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 17 MTF1 MYT1 OSR1 PRDM9 SALL 1 2 3 4 SP 1 2 4 7 8 TSHZ3 WT1 Zbtb7 7A 7B ZBTB 11 16 17 20 32 33 40 zinc finger 3 7 9 10 19 22 24 33B 34 35 41 43 44 51 74 143 146 148 165 202 217 219 238 239 259 267 268 281 295 300 318 330 346 350 365 366 384 423 451 452 471 593 638 644 649 655 (2.4) Cys6 HIVEP1 (2.5) Alternating composition AIRE DIDO1 GRLF1 ING 1 2 4 JARID 1A 1B 1C 1D 2 JMJD1B (2.6) WRKY WRKY (3) Helix-turn-helix domains (3.1) Homeodomain ARX CDX 1 2 CRX CUTL1 DBX 1 2 DLX 3 4 5 EMX 1 2 EN 1 2 FHL 1 2 3 HESX1 HHEX HLX Homeobox A1 A2 A3 A4 A5 A7 A9 A10 A11 A13 B1 B2 B3 B4 B5 B6 B7 B8 B9 B13 C4 C5 C6 C8 C9 C10 C11 C12 C13 D1 D3 D4 D8 D9 D10 D11 D12 D13 HOPX IRX 1 2 3 4 5 6 MKX LMX 1A 1B MEIS 1 2 MEOX2 MNX1 MSX 1 2 NANOG NKX 2-1 2-2 2-3 2-5 3-1 3-2 6-1 6-2 NOBOX PBX 1 2 3 PHF 1 3 6 8 10 16 17 20 21A PHOX 2A 2B PITX 1 2 3 POU domain PIT-1 BRN-3: A B C Octamer transcription factor: 1 2 3/4 6 7 11 OTX 1 2 PDX1 SATB2 SHOX2 SIX 1 2 3 4 5 VAX1 ZEB 1 2 (3.2) Paired box PAX 1 2 3 4 5 6 7 8 9 PRRX 1 2 RAX (3.3) Fork head / winged helix E2F 1 2 3 4 5 FOX proteins A1 A2 A3 C1 C2 D3 D4 E1 E3 F1 G1 H1 I1 J1 J2 K1 K2 L2 M1 N1 N3 O1 O3 O4 P1 P2 P3 P4 (3.4) Heat shock factors HSF 1 2 4 (3.5) Tryptophan clusters ELF 2 4 5 EGF ELK 1 3 4 ERF ETS 1 2 ERG SPIB ETV 1 4 5 6 FLI1 Interferon regulatory factors 1 2 3 4 5 6 7 8 MYB MYBL2 (3.6) TEA domain transcriptional enhancer factor 1 2 3 4 (4) β-Scaffold factors with minor groove contacts (4.1) Rel homology region NF-κB NFKB1 NFKB2 REL RELA RELB NFAT C1 C2 C3 C4 5 (4.2) STAT STAT 1 2 3 4 5 6 (4.3) p53 p53 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF TP63 (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group BBX HMGB 1 2 3 4 HMGN 1 2 3 4 HNF 1A 1B LEF1 SOX 1 2 3 4 5 6 8 9 10 11 12 13 14 15 18 21 SRY SSRP1 TCF 3 4 TOX 1 2 3 4 (4.9) Grainyhead TFCP2 (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1 (0.3) Pocket domain Rb RBL1 RBL2 (0.5) AP-2/EREBP-related factors Apetala 2 EREBP B3 (0.6) Miscellaneous ARID 1A 1B 2 3A 3B 4A CAP IFI 16 35 MLL 2 3 T1 MNDA NFY A B C Rho/Sigma see also transcription factor/coregulator deficiencies v t e Cell cycle proteins Cyclin A (A1, A2) B (B1, B2, B3) D (D1, D2, D3) E (E1, E2) CDK 1 2 3 4 5 6 7 8 9 10 CDK-activating kinase CDK inhibitor INK4a/ARF (p14arf/p16, p15, p18, p19) cip/kip (p21, p27, p57) P53 p63 p73 family p53 p63 p73 Other Cdc2 Cdc25 Cdc42 Cellular apoptosis susceptibility protein E2F Maturation promoting factor Wee Cullin (CUL7) Phases and checkpoints Interphase G1 phase S phase G2 phase M phase Mitosis (Preprophase Prophase Prometaphase Metaphase Anaphase Telophase) Cytokinesis Cell cycle checkpoints Restriction point Spindle checkpoint Postreplication checkpoint Other cellular phases Apoptosis G0 phase Meiosis Retrieved from "https://en.wikipedia.org/w/index.php?title=TP63&oldid=803949318" Categories: Genes on human chromosome 3


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TP63 - Photos and All Basic Informations

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Protein Data BankGene NomenclatureMendelian Inheritance In ManMouse Genome InformaticsHomoloGeneGeneCardsChromosome 3 (human)ChromosomeChromosome 3 (human)Chromosome 3 (human)Genomic Location For TP63Genomic Location For TP63Locus (genetics)Base PairBase PairChromosome 16 (mouse)ChromosomeChromosome 16 (mouse)Genomic Location For TP63Genomic Location For TP63Locus (genetics)Base PairBase PairGene ExpressionGene OntologyEntrezEnsemblUniProtPubMedWikidataProteinGeneP53P73Transcription FactorMesenchymeEpitheliumEctrodactyly-ectodermal Dysplasia-cleft SyndromeCleft Lip/palate Syndrome 3EctrodactylyHay–Wells SyndromeAcro–dermato–ungual–lacrimal–tooth SyndromeLimb-mammary SyndromeRap-Hodgkin SyndromeOrofacial CleftImmunostainingAdenocarcinomaProstate CancerProstateCell (biology)MalignantProtein-protein InteractionHNRPABMir-203 MicroRNAAMACREnsembl Genome Database ProjectEnsembl Genome Database ProjectDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierPubMed IdentifierDigital Object IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed CentralPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed CentralPubMed IdentifierDigital Object IdentifierPubMed CentralPubMed IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed CentralPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierPubMed IdentifierDigital Object IdentifierPubMed CentralPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed CentralPubMed IdentifierMedical Subject HeadingsUCSC Genome BrowserUCSC Genome BrowserTemplate:PDB GalleryTemplate Talk:PDB Gallery1rg6: Solution Structure Of The C-terminal Domain Of P63Template:Tumor Suppressor Genes And OncogenesTemplate Talk:Tumor Suppressor Genes And OncogenesNeoplasmTumor Suppressor GeneOncogeneLigand (biochemistry)Growth FactorPlatelet-derived Growth FactorHepatocyte Growth FactorReceptor (biochemistry)Wnt Signaling PathwayCDH1 (gene)Hedgehog Signaling PathwayPTCH1TGF Beta Signaling PathwayTGF Beta Receptor 2Receptor Tyrosine KinaseErbBEpidermal Growth Factor ReceptorHER2/neuERBB3C-MetRET Proto-oncogeneJAK-STAT Signaling PathwayCD117CD135Intracellular Signaling Peptides And ProteinsWnt Signaling PathwayBeta-cateninAdenomatosis Polyposis ColiTGF Beta Signaling PathwayMothers Against Decapentaplegic Homolog 2Mothers Against Decapentaplegic Homolog 4Akt/PKB Signaling PathwayAKTPTEN (gene)Hippo Signaling PathwayMerlin (protein)MAPK/ERK PathwayRas (protein)HRASC-RafNeurofibromin 1Proto-oncogene Tyrosine-protein Kinase SrcMaspinCell NucleusCell CycleCyclin-dependent Kinase 4Cyclin DCyclin EP53Retinoblastoma ProteinWT1P16 (gene)P14arfDNA RepairFanconi AnemiaBRCA1BRCA2Ubiquitin LigaseCBL (gene)Mdm2Von Hippel–Lindau Tumor SuppressorTranscription FactorAP-1 Transcription FactorC-FosC-junMycKLF6MitochondrionInhibitor Of ApoptosisSDHBSDHDBcl-2Notch SignalingStathminTemplate:Transcription Factors And Intracellular ReceptorsTemplate Talk:Transcription Factors And Intracellular ReceptorsTranscription FactorIntracellular ReceptorLeucine ZipperBZIP DomainActivating Transcription FactorApoptosis-antagonizing Transcription FactorATF1Activating Transcription Factor 2ATF3ATF4ATF5ATF6ATF7AP-1 Transcription FactorC-FosFOSBFOSL1FOSL2Jun Dimerization ProteinC-junJUNBJunDBACH1BACH2BATF (gene)BLZF1Ccaat-enhancer-binding ProteinsCEBPACEBPBCEBPGCEBPDCEBPECCAAT/enhancer Binding Protein ZetaCREBCREB1CREB3CREBL1CAMP Responsive Element ModulatorDBP (gene)DNA Damage-inducible Transcript 3GABPAGcn4HLF (gene)MAF (gene)MAFB (gene)MAFF (gene)MAFGMAFKNFE2NFE2L1NFE2L2NFE2L3NFIL3NRL (gene)NRF1NFE2L2NFE2L3XBP1Basic Helix-loop-helixATOH1Aryl Hydrocarbon ReceptorAryl Hydrocarbon Receptor RepressorAryl Hydrocarbon Receptor Nuclear TranslocatorASCL1BHLHB2BHLHB3BHLHA9ARNTLARNTLARNTL2CLOCKEPAS1FIGLAHAND1HAND2HES5HES6HEY1HEY2HEYLHES1Hypoxia-inducible FactorsHIF1AHIF3AID1ID2ID3 (gene)ID4LYL1MESP2MXD4MYCL1N-MycMyogenic Regulatory FactorsMyoDMyogeninMYF5MYF6NeurogeninsNEUROG1NEUROG2NEUROG3NeuroDNEUROD1NEUROD2NPAS1NPAS2NPAS3OLIG1OLIG2Pho4ScleraxisSIM1SIM2TAL1TAL2Twist Transcription FactorUSF1Basic Helix-loop-helix Leucine Zipper Transcription FactorsTFAP4MAX (gene)MXD3Microphthalmia-associated Transcription FactorMNT (gene)MLX (gene)MXI1MycSterol Regulatory Element-binding ProteinSREBF1SREBF2Nuclear Factor INFIANFIB (gene)NFIC (gene)NFIXSMAD (protein)R-SMADMothers Against Decapentaplegic Homolog 1Mothers Against Decapentaplegic Homolog 2Mothers Against Decapentaplegic Homolog 3Mothers Against Decapentaplegic Homolog 5Mothers Against Decapentaplegic Homolog 9I-SMADMothers Against Decapentaplegic Homolog 6Mothers Against Decapentaplegic Homolog 7Mothers Against Decapentaplegic Homolog 4RFX1RFX2RFX3RFX4RFX5RFX6RFXANKActivating Protein 2TFAP2ATFAP2BTFAP2CTFAP2DTFAP2EZinc FingerNuclear ReceptorThyroid Hormone ReceptorThyroid Hormone Receptor AlphaThyroid Hormone Receptor BetaConstitutive Androstane ReceptorFarnesoid X ReceptorLiver X ReceptorLiver X Receptor AlphaLiver X Receptor BetaPeroxisome Proliferator-activated ReceptorPeroxisome Proliferator-activated Receptor AlphaPeroxisome Proliferator-activated Receptor DeltaPeroxisome Proliferator-activated Receptor GammaPregnane X ReceptorRetinoic Acid ReceptorRetinoic Acid Receptor AlphaRetinoic Acid Receptor BetaRetinoic Acid Receptor GammaRAR-related Orphan ReceptorRAR-related Orphan Receptor AlphaRAR-related Orphan Receptor BetaRAR-related Orphan Receptor GammaRev-ErbARev-ErbA AlphaRev-ErbA BetaCalcitriol ReceptorChicken Ovalbumin Upstream Promoter-transcription FactorCOUP-TFICOUP-TFIIV-erbA-related GeneHepatocyte Nuclear Factor 4Hepatocyte Nuclear Factor 4 AlphaHepatocyte Nuclear Factor 4 GammaPhotoreceptor Cell-specific Nuclear ReceptorRetinoid X ReceptorRetinoid X Receptor AlphaRetinoid X Receptor BetaRetinoid X Receptor GammaTesticular ReceptorTesticular Receptor 2Testicular Receptor 4TLXSteroid Hormone ReceptorAndrogen ReceptorEstrogen ReceptorEstrogen Receptor AlphaEstrogen Receptor BetaGlucocorticoid ReceptorMineralocorticoid ReceptorProgesterone ReceptorEstrogen-related ReceptorEstrogen-related Receptor AlphaEstrogen-related Receptor BetaEstrogen-related Receptor GammaNur (biology)Nerve Growth Factor IBNeuron-derived Orphan Receptor 1Nuclear Receptor Related-1 ProteinLiver Receptor Homolog-1Steroidogenic Factor 1Germ Cell Nuclear FactorDAX1Small Heterodimer PartnerGATA Transcription FactorGATA1GATA2GATA3GATA4GATA5GATA6MTA1MTA2MTA3Tricho-rhino-phalangeal Syndrome Type 1General Transcription FactorTranscription Factor II ATranscription Factor II BTranscription Factor II DTranscription Factor II EGTF2E1GTF2E2Transcription Factor II FGTF2F1GTF2F2Transcription Factor II HGTF2H1GTF2H2GTF2H4GTF2IGTF3AGTF3C1GTF3C2ATBF1B-cell CLL/lymphomaBCL6BCL11ABCL11BCTCFE4F1Early Growth Response ProteinsEGR1EGR2EGR3EGR4ERV3GFI1Kruppel-like FactorsGLI1GLI2GLI3RE1-silencing Transcription FactorGLIS1GLIS2YY1HIC1HIC2HIVEP1HIVEP2HIVEP3IKZF1IKZF2IKZF3ILF2ILF3Kruppel-like FactorsKLF1KLF2KLF3KLF4KLF5KLF6KLF7KLF8KLF9KLF10KLF11KLF12KLF13KLF14KLF15KLF17MTF1MYT1OSR1PRDM9SALL1SALL2SALL3SALL4Sp1 Transcription FactorSP2 (gene)SP4 (gene)Sp7 Transcription FactorSp8 Transcription FactorTSHZ3WT1Zbtb7ZBTB7AZBTB7BZBTB11Zinc Finger And BTB Domain-containing Protein 16ZBTB17ZBTB20ZBTB32ZBTB33ZBTB40ZNF3ZNF7CNBPZNF10ZNF19ZNF22ZNF24ZNF33BZNF34ZNF35ZNF41ZNF43ZNF44BCL6ZNF74ZNF143ZNF146ZNF148Zinc Finger Protein 165ZNF202ZNF217ZNF219ZNF238ZNF239ZNF259ZNF267EGR1ZNF281ZNF295ZNF300ZNF318ZNF330ZNF346ZNF350ZNF365ZNF366ZNF384ZNF423ZNF451ZNF452ZNF471ZNF593ZNF638ZNF644ZNF649ZNF655HIVEP1Autoimmune RegulatorDIDO1GRLF1ING1ING2ING4KDM5AKDM5BKDM5CKDM5DJARID2KDM3BWRKY Protein DomainHelix-turn-helixHomeodomain FoldAristaless Related HomeoboxCDX1CDX2CRX (gene)CUTL1DBX1DBX2DLX Gene FamilyDLX3 (gene)DLX4DLX5EMX HomeogeneEMX1EMX2EN1 (gene)EN2 (gene)FHL1FHL2FHL3HESX1HHEXHLX (gene)HomeoboxHomeobox A1HOXA2HOXA3HOXA4HOXA5HOXA7HOXA9Homeobox A10HOXA11HOXA13HOXB1HOXB2HOXB3HOXB4HOXB5HOXB6HOXB7HOXB8HOXB9HOXB13HOXC4HOXC5HOXC6HOXC8HOXC9HOXC10HOXC11HOXC12HOXC13HOXD1HOXD3HOXD4HOXD8HOXD9HOXD10HOXD11HOXD12HOXD13HOPXIroquois Homeobox FactorIRX1IRX2IRX3IRX4IRX5IRX6MKXLMX1ALMX1BMEIS1MEIS2MEOX2MNX1MSX1Msh Homeobox 2Homeobox Protein NANOGNKX-homeodomain FactorNK2 Homeobox 1NKX2-2NKX2-3Homeobox Protein Nkx-2.5NKX3-1NKX3-2NKX6-1NKX6-2NOBOXPBX1PBX2PBX3PHF1PHF3PHF6PHF8PHF10PHF16PHF17PHF20PHF21APHOX2APHOX2BPITX1PITX2PITX3POU DomainPituitary-specific Positive Transcription Factor 1BRN-3POU4F1POU4F2POU4F3Octamer Transcription FactorPOU2F1Oct-2Oct-4POU3F1POU3F2POU3F4OTX1Orthodenticle Homeobox 2PDX1SATB2SHOX2SIX1SIX2SIX3SIX4SIX5VAX1ZEB1ZEB2Pax GenesPAX1PAX2PAX3PAX4PAX5PAX6PAX7PAX8PAX9PRRX1PRRX2Retinal Homeobox Protein RxFOX ProteinsWinged-helix Transcription FactorsE2FE2F1E2F2E2F3E2F4E2F5FOX ProteinsFOXA1FOXA2FOXA3Forkhead Box C1FOXC2FOXD3FOXD4FOXE1FOXE3FOXF1FOXG1FOXH1FOXI1FOXJ1FOXJ2FOXK1FOXK2Forkhead Box L2FOXM1FOXN1FOXN3FOXO1FOXO3FOXO4FOXP1FOXP2FOXP3FOXP4Heat Shock FactorHeat Shock FactorHSF1HSF2HSF4ELF2ELF4ELF5EHF (gene)ELK1ELK3ELK4ERF (gene)ETS Transcription Factor FamilyETS1ETS2ERG (gene)SPIBETV1ETV4ERM Transcription FactorETV6FLI1Interferon Regulatory FactorsIRF1IRF2IRF3IRF4IRF5IRF6IRF7IRF8MYB (gene)MYBL2TEAD1TEAD2TEAD3TEAD4Rel Homology DomainNF-κBNFKB1NFKB2RELRELARELBNFATNFATC1NFATC2NFATC3NFATC4NFAT5STAT ProteinSTAT ProteinSTAT1STAT2STAT3STAT4STAT5STAT6P53T-boxTBX1TBX2TBX3TBX5 (gene)TBX19TBX21TBX22TBR1EomesoderminBrachyuryMyelin Regulatory FactorMADS-boxMef2Myocyte-specific Enhancer Factor 2AMEF2BMEF2CMEF2DSerum Response FactorTATA-binding ProteinTATA-binding ProteinTBPL1High-mobility GroupBBX (gene)HMGB1HMGB2HMGB3HMGB4HMGNHMGN1HMGN2HMGN3HMGN4HNF1AHNF1BLymphoid Enhancer-binding Factor 1SOX Gene FamilySOX1SOX2SOX3SOX4SOX5SOX6SOX8SOX9SOX10SOX11SOX12SOX13SOX14SOX15SOX18SOX21Testis Determining FactorStructure Specific Recognition Protein 1TCF3TCF7L2TOXTOX2TOX3TOX4TFCP2CSDA (gene)Y Box Binding Protein 1Core Binding FactorCBFA2T2CBFA2T3RUNX1RUNX2RUNX3RUNX1T1HMGAHMGA1HMGA2HBP1Pocket Protein FamilyRetinoblastoma ProteinRetinoblastoma-like Protein 1Retinoblastoma-like Protein 2Apetala 2Ethylene-responsive Element Binding ProteinApetala 2Ethylene-responsive Element Binding ProteinB3 DomainARID1AARID1BARID2ARID3AARID3BARID4ACatabolite Activator ProteinIFI16IFI35MLL (gene)MLL2MLL3MLLT1MNDANFYANFYBNFYCRho FactorSigma FactorTemplate:Transcription Factor And Coregulator DeficienciesTemplate:Cell Cycle ProteinsTemplate Talk:Cell Cycle ProteinsCell CycleProteinCyclinCyclin ACyclin A1Cyclin A2Cyclin BCyclin B1Cyclin B2Cyclin DCyclin D1Cyclin D2Cyclin D3Cyclin ECyclin E1Cyclin E2Cyclin-dependent KinaseCyclin-dependent Kinase 1Cyclin-dependent Kinase 2Cyclin-dependent Kinase 3Cyclin-dependent Kinase 4Cyclin-dependent Kinase 5Cyclin-dependent Kinase 6Cyclin-dependent Kinase 7Cyclin-dependent Kinase 8Cyclin-dependent Kinase 9Cyclin-dependent Kinase 10CDK-activating KinaseCyclin-dependent Kinase Inhibitor ProteinCell CycleP14arfP16CDKN2BCDKN2CCDKN2DCell CycleP21CDKN1BCyclin-dependent Kinase Inhibitor 1CP53 P63 P73 FamilyP53P73Cdk1Cdc25CDC42Cellular Apoptosis Susceptibility ProteinE2FMaturation Promoting FactorWee1CullinCUL7InterphaseG1 PhaseS PhaseG2 PhaseCell DivisionMitosisPreprophaseProphasePrometaphaseMetaphaseAnaphaseTelophaseCytokinesisCell Cycle CheckpointRestriction PointSpindle CheckpointPostreplication CheckpointApoptosisG0 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