Contents 1 Chromosome silencing 2 Recombination 3 References 4 External links


Chromosome silencing[edit] In mammals, surveillance mechanisms remove meiotic cells in which synapsis is defective. One such surveillance mechanism is meiotic silencing that involves the transcriptional silencing of genes on asynapsed chromosomes.[4] Any chromosome region, either in males or females, that is asynapsed is subject to meiotic silencing.[5] ATR, BRCA1 and gammaH2AX localize to unsynapsed chromosomes at the pachytene stage of meiosis in human oocytes and this may lead to chromosome silencing.[6] The DNA damage response protein TOPBP1 has also been identified as a crucial factor in meiotic sex chromosome silencing.[4] DNA double-strand breaks appear to be initiation sites for meiotic silencing.[4]


Recombination[edit] In female Drosophila melanogaster fruit flies, meiotic chromosome synapsis occurs in the absence of recombination.[7] Thus synapsis in Drosophila is independent of meiotic recombination, consistent with the view that synapsis is a precondition required for the initiation of meiotic recombination. Meiotic recombination is also unnecessary for homologous chromosome synapsis in the nematode Caenorhabditis elegans.[8]


References[edit] ^ Revenkova E, Jessberger R (2006). "Shaping meiotic prophase chromosomes: cohesins and synaptonemal complex proteins" (PDF). Chromosoma. 115 (3): 235–40. doi:10.1007/s00412-006-0060-x. PMID 16518630.  ^ Page J, de la Fuente R, Gómez R, Calvente A, Viera A, Parra M, Santos J, Berríos S, Fernández-Donoso R, Suja J, Rufas J (2006). "Sex chromosomes, synapsis, and cohesins: a complex affair" (PDF). Chromosoma. 115 (3): 250–9. doi:10.1007/s00412-006-0059-3. PMID 16544151.  ^ McKee B (2004). "Homologous pairing and chromosome dynamics in meiosis and mitosis". Biochim Biophys Acta. 1677 (1-3): 165–80. doi:10.1016/j.bbaexp.2003.11.017. PMID 15020057.  ^ a b c ElInati E, Russell HR, Ojarikre OA, Sangrithi M, Hirota T, de Rooij DG, McKinnon PJ, Turner JM (2017). "DNA damage response protein TOPBP1 regulates X chromosome silencing in the mammalian germ line". Proc. Natl. Acad. Sci. U.S.A. 114 (47): 12536–12541. doi:10.1073/pnas.1712530114. PMID 29114052.  ^ Turner JM (2015). "Meiotic Silencing in Mammals". Annu. Rev. Genet. 49: 395–412. doi:10.1146/annurev-genet-112414-055145. PMID 26631513.  ^ Garcia-Cruz R, Roig I, Robles P, Scherthan H, Garcia Caldés M (2009). "ATR, BRCA1 and gammaH2AX localize to unsynapsed chromosomes at the pachytene stage in human oocytes". Reprod. Biomed. Online. 18 (1): 37–44. PMID 19146767.  ^ McKim KS, Green-Marroquin BL, Sekelsky JJ, Chin G, Steinberg C, Khodosh R, Hawley RS (1998). "Meiotic synapsis in the absence of recombination". Science. 279 (5352): 876–8. PMID 9452390.  ^ Dernburg AF, McDonald K, Moulder G, Barstead R, Dresser M, Villeneuve AM (1998). "Meiotic recombination in C. elegans initiates by a conserved mechanism and is dispensable for homologous chromosome synapsis". Cell. 94 (3): 387–98. PMID 9708740. 


External links[edit] Look up synapsis in Wiktionary, the free dictionary. UC Berkeley video of chromosome end migration and match assessment during prophase This cell biology article is a stub. You can help Wikipedia by expanding it. v t e Retrieved from "https://en.wikipedia.org/w/index.php?title=Synapsis&oldid=816535772" Categories: Cell biologyCytogeneticsCell biology stubsHidden categories: All stub articles


Navigation menu Personal tools Not logged inTalkContributionsCreate accountLog in Namespaces ArticleTalk Variants Views ReadEditView history More Search Navigation Main pageContentsFeatured contentCurrent eventsRandom articleDonate to WikipediaWikipedia store Interaction HelpAbout WikipediaCommunity portalRecent changesContact page Tools What links hereRelated changesUpload fileSpecial pagesPermanent linkPage informationWikidata itemCite this page Print/export Create a bookDownload as PDFPrintable version Languages EspañolFrançaisHrvatskiPortuguêsРусскийதமிழ்中文 Edit links This page was last edited on 21 December 2017, at 23:46. Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization. Privacy policy About Wikipedia Disclaimers Contact Wikipedia Developers Cookie statement Mobile view (window.RLQ=window.RLQ||[]).push(function(){mw.config.set({"wgPageParseReport":{"limitreport":{"cputime":"0.172","walltime":"0.213","ppvisitednodes":{"value":566,"limit":1000000},"ppgeneratednodes":{"value":0,"limit":1500000},"postexpandincludesize":{"value":21165,"limit":2097152},"templateargumentsize":{"value":184,"limit":2097152},"expansiondepth":{"value":8,"limit":40},"expensivefunctioncount":{"value":0,"limit":500},"entityaccesscount":{"value":0,"limit":400},"timingprofile":["100.00% 185.769 1 -total"," 60.14% 111.717 1 Template:Reflist"," 48.23% 89.590 8 Template:Cite_journal"," 17.86% 33.171 1 Template:Distinguish"," 7.17% 13.324 1 Template:Cell-biology-stub"," 6.34% 11.774 1 Template:Asbox"," 5.02% 9.334 1 Template:Wiktionary"," 4.67% 8.675 2 Template:For"," 3.97% 7.378 1 Template:Sister_project"," 2.66% 4.934 1 Template:Side_box"]},"scribunto":{"limitreport-timeusage":{"value":"0.093","limit":"10.000"},"limitreport-memusage":{"value":3018034,"limit":52428800}},"cachereport":{"origin":"mw1219","timestamp":"20180113061017","ttl":1900800,"transientcontent":false}}});});(window.RLQ=window.RLQ||[]).push(function(){mw.config.set({"wgBackendResponseTime":83,"wgHostname":"mw1324"});});


Synapsis - Photos and All Basic Informations

Synapsis More Links

SynapseSynapsidSynopsis (disambiguation)Synapsis (plant)CopriniMeiosisChromosomal CrossoverMeiosisCytoskeletonSynaptonemal ComplexAutosomeSex ChromosomesMitosisGenetic RecombinationChiasma (genetics)MetaphaseGenetic VariabilityGenetic RecombinationMammalMeiosisTranscription (biology)GeneChromosomeAtaxia Telangiectasia And Rad3 RelatedBRCA1H2AFXOocyteDNA Damage (naturally Occurring)TOPBP1Drosophila MelanogasterHomologous RecombinationHomologous ChromosomeCaenorhabditis ElegansDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierPubMed IdentifierPubMed IdentifierPubMed IdentifierCell BiologyWikipedia:StubTemplate:Cell-biology-stubTemplate Talk:Cell-biology-stubHelp:CategoryCategory:Cell BiologyCategory:CytogeneticsCategory:Cell Biology StubsCategory:All Stub ArticlesDiscussion About Edits From This IP Address [n]A List Of Edits Made From This IP Address [y]View The Content Page [c]Discussion About The Content Page [t]Edit This Page [e]Visit The Main Page [z]Guides To Browsing WikipediaFeatured Content – The Best Of WikipediaFind Background Information On Current EventsLoad A Random Article [x]Guidance On How To Use And Edit WikipediaFind Out About WikipediaAbout The Project, What You Can Do, Where To Find ThingsA List Of Recent Changes In The Wiki [r]List Of All English Wikipedia Pages Containing Links To This Page [j]Recent Changes In Pages Linked From This Page [k]Upload Files [u]A List Of All Special Pages [q]Wikipedia:AboutWikipedia:General Disclaimer



view link view link view link view link view link