Contents 1 Mitosis 2 Meiosis 3 See also 4 References


Mitosis[edit] Mitotic recombination is primarily a result of DNA repair processes responding to spontaneous or induced damages.[2][3] (Also reviewed in Bernstein and Bernstein, pp 220–221).[4] Homologous recombinational repair during mitosis is largely limited to interaction between nearby sister chromatids that are present in a cell subsequent to DNA replication but prior to cell division. Due to the special nearby relationship they share, sister chromatids are not only preferred over distant homologous chromatids as substrates for recominational repair, but have the capacity to repair more DNA damage than do homologs.[1]


Meiosis[edit] Studies with the budding yeast Saccharomyces cerevisiae[5] indicate that inter-sister recombination occurs frequently during meiosis, and up to one-third of all recombination events occur between sister chromatids.


See also[edit] Biorientation Sister chromatid exchange


References[edit] ^ a b Kadyk, Lc; Hartwell, Lh (Oct 1992). "Sister chromatids are preferred over homologs as substrates for recombinational repair in Saccharomyces cerevisiae" (Free full text). Genetics. 132 (2): 387–402. ISSN 0016-6731. PMC 1205144 . PMID 1427035.  ^ Moynahan ME, Jasin M (2010). "Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis". Nat. Rev. Mol. Cell Biol. 11 (3): 196–207. doi:10.1038/nrm2851. PMC 3261768 . PMID 20177395.  ^ Symington LS, Rothstein R, Lisby M (2014). "Mechanisms and regulation of mitotic recombination in Saccharomyces cerevisiae". Genetics. 198 (3): 795–835. doi:10.1534/genetics.114.166140. PMC 4224172 . PMID 25381364.  ^ Bernstein C, Bernstein H. (1991) Aging, Sex, and DNA Repair. Academic Press, San Diego. ISBN 978-0120928606 partly available at https://books.google.com/books?id=BaXYYUXy71cC&pg=PA3&lpg=PA3&dq=Aging,+Sex,+and+DNA+Repair&source=bl&ots=9E6VrRl7fJ&sig=kqUROJfBM6EZZeIrkuEFygsVVpo&hl=en&sa=X&ei=z8BqUpi7D4KQiALC54Ew&ved=0CFUQ6AEwBg#v=onepage&q=Aging%2C%20Sex%2C%20and%20DNA%20Repair&f=false ^ Goldfarb T, Lichten M (2010). "Frequent and efficient use of the sister chromatid for DNA double-strand break repair during budding yeast meiosis". PLoS Biol. 8 (10): e1000520. doi:10.1371/journal.pbio.1000520. PMC 2957403 . PMID 20976044.  Retrieved from "https://en.wikipedia.org/w/index.php?title=Sister_chromatids&oldid=816735733" Categories: Molecular genetics


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