External links[edit] A naturally occurring p73 mutation in a p73-p53 double-mutant lung cancer cell line encodes p73α protein with a dominant-negative function TP73 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)


Further reading[edit] Kaghad M, Bonnet H, Yang A, et al. (August 1997). "Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers". Cell. 90 (4): 809–19. doi:10.1016/S0092-8674(00)80540-1. PMID 9288759.  Levrero M, De Laurenzi V, Costanzo A, Gong J, Wang JY, Melino G (May 2000). "The p53/p63/p73 family of transcription factors: overlapping and distinct functions". J. Cell Sci. 113 (10): 1661–70. PMID 10769197.  Pozniak CD, Radinovic S, Yang A, McKeon F, Kaplan DR, Miller FD (July 2000). "An anti-apoptotic role for the p53 family member, p73, during developmental neuron death". Science. 289 (5477): 304–6. doi:10.1126/science.289.5477.304. PMID 10894779.  Yang A, Walker N, Bronson R, et al. (March 2000). "p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours". Nature. 404 (6773): 99–103. doi:10.1038/35003607. PMID 10716451.  Kaelin WG (1999). "The emerging p53 gene family". J. Natl. Cancer Inst. 91 (7): 594–8. doi:10.1093/jnci/91.7.594. PMID 10203277.  Davis PK, Dowdy SF (2001). "p73". Int. J. Biochem. Cell Biol. 33 (10): 935–9. doi:10.1016/S1357-2725(01)00073-5. PMID 11470228.  Salomoni P, Pandolfi PP (2002). "The role of PML in tumor suppression". Cell. 108 (2): 165–70. doi:10.1016/S0092-8674(02)00626-8. PMID 11832207.  Melino G (2004). "p73, the "assistant" guardian of the genome?". Ann. N. Y. Acad. Sci. 1010: 9–15. doi:10.1196/annals.1299.002. PMID 15033688.  Jacobs WB, Walsh GS, Miller FD (2005). "Neuronal survival and p73/p63/p53: a family affair". The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 10 (5): 443–55. doi:10.1177/1073858404263456. PMID 15359011.  Rossi M, Sayan AE, Terrinoni A, et al. (2005). "Mechanism of induction of apoptosis by p73 and its relevance to neuroblastoma biology". Ann. N. Y. Acad. Sci. 1028: 143–9. doi:10.1196/annals.1322.015. PMID 15650240.  Dobbelstein M, Strano S, Roth J, Blandino G (2005). "p73-induced apoptosis: a question of compartments and cooperation". Biochem. Biophys. Res. Commun. 331 (3): 688–93. doi:10.1016/j.bbrc.2005.03.155. PMID 15865923.  Ramadan S, Terrinoni A, Catani MV, et al. (2005). "p73 induces apoptosis by different mechanisms". Biochem. Biophys. Res. Commun. 331 (3): 713–7. doi:10.1016/j.bbrc.2005.03.156. PMID 15865927.  Harms KL, Chen X (2006). "p19ras brings a new twist to the regulation of p73 by Mdm2". Sci. STKE. 2006 (337): pe24. doi:10.1126/stke.3372006pe24. PMID 16738062.  Marabese M, Vikhanskaya F, Broggini M (2007). "p73: a chiaroscuro gene in cancer". Eur. J. Cancer. 43 (9): 1361–72. doi:10.1016/j.ejca.2007.01.042. PMID 17428654.  Levy D, Adamovich Y, Reuven N, Shaul Y (2007). "The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73". Cell Death and Differentiation. 14 (4): 743–51. doi:10.1038/sj.cdd.4402063. PMID 17110958.  v t e PDB gallery 1cok: STRUCTURE OF THE C-TERMINAL DOMAIN OF P73  1dxs: CRYSTAL STRUCTURE OF THE C-TERMINAL STERILE ALPHA MOTIF (SAM) DOMAIN OF HUMAN P73 ALPHA SPLICE VARIANT  v t e Neoplasm: Tumor suppressor genes/proteins and Oncogenes/Proto-oncogenes Ligand Growth factors ONCO c-Sis/PDGF HGF Receptor Wnt signaling pathway TSP CDH1 Hedgehog signaling pathway TSP PTCH1 TGF beta signaling pathway TSP TGF beta receptor 2 Receptor tyrosine kinase ONCO ErbB/c-ErbB HER2/neu Her 3 c-Met c-Ret JAK-STAT signaling pathway ONCO c-Kit Flt3 Intracellular signaling P+Ps Wnt signaling pathway ONCO Beta-catenin TSP APC TGF beta signaling pathway TSP SMAD2 SMAD4 Akt/PKB signaling pathway ONCO c-Akt TSP PTEN Hippo signaling pathway TSP Neurofibromin 2/Merlin MAPK/ERK pathway ONCO c-Ras HRAS c-Raf TSP Neurofibromin 1 Other/unknown ONCO c-Src TSP Maspin Nucleus Cell cycle ONCO CDK4 Cyclin D Cyclin E TSP p53 pRb WT1 p16/p14arf DNA repair/Fanconi TSP BRCA1 BRCA2 Ubiquitin ligase ONCO CBL MDM2 TSP VHL Transcription factor ONCO AP-1 c-Fos c-Jun c-Myc TSP KLF6 Mitochondrion Apoptosis inhibitor SDHB SDHD Other/ungrouped c-Bcl-2 Notch Stathmin v t e Cell cycle proteins Cyclin A (A1, A2) B (B1, B2, B3) D (D1, D2, D3) E (E1, E2) CDK 1 2 3 4 5 6 7 8 9 10 CDK-activating kinase CDK inhibitor INK4a/ARF (p14arf/p16, p15, p18, p19) cip/kip (p21, p27, p57) P53 p63 p73 family p53 p63 p73 Other Cdc2 Cdc25 Cdc42 Cellular apoptosis susceptibility protein E2F Maturation promoting factor Wee Cullin (CUL7) Phases and checkpoints Interphase G1 phase S phase G2 phase M phase Mitosis (Preprophase Prophase Prometaphase Metaphase Anaphase Telophase) Cytokinesis Cell cycle checkpoints Restriction point Spindle checkpoint Postreplication checkpoint Other cellular phases Apoptosis G0 phase Meiosis ^ a b c GRCh38: Ensembl release 89: ENSG00000078900 - Ensembl, May 2017 ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029026 - Ensembl, May 2017 ^ "Human PubMed Reference:".  ^ "Mouse PubMed Reference:".  Retrieved from "https://en.wikipedia.org/w/index.php?title=P73&oldid=809391541" Categories: Genes on human chromosome 1ProteinsTumor suppressor genes


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P73 - Photos and All Basic Informations

P73 More Links

Protein Data BankGene NomenclatureMendelian Inheritance In ManMouse Genome InformaticsHomoloGeneGeneCardsChromosome 1 (human)ChromosomeChromosome 1 (human)Chromosome 1 (human)Genomic Location For TP73Genomic Location For TP73Locus (genetics)Base PairBase PairChromosome 4 (mouse)ChromosomeChromosome 4 (mouse)Genomic Location For TP73Genomic Location For TP73Locus (genetics)Base PairBase PairGene ExpressionGene OntologyEntrezEnsemblUniProtPubMedWikidataP53Tumor Suppressor GeneCell CycleApoptosisSplice VariantPromoter (biology)DNAMedical Subject HeadingsDigital Object IdentifierPubMed IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierTemplate:PDB GalleryTemplate Talk:PDB Gallery1cok: STRUCTURE OF THE C-TERMINAL DOMAIN OF P731dxs: CRYSTAL STRUCTURE OF THE C-TERMINAL STERILE ALPHA MOTIF (SAM) DOMAIN OF HUMAN P73 ALPHA SPLICE VARIANTTemplate:Tumor Suppressor Genes And OncogenesTemplate Talk:Tumor Suppressor Genes And OncogenesNeoplasmTumor Suppressor GeneOncogeneLigand (biochemistry)Growth FactorPlatelet-derived Growth FactorHepatocyte Growth FactorReceptor (biochemistry)Wnt Signaling PathwayCDH1 (gene)Hedgehog Signaling PathwayPTCH1TGF Beta Signaling PathwayTGF Beta Receptor 2Receptor Tyrosine KinaseErbBEpidermal Growth Factor ReceptorHER2/neuERBB3C-MetRET Proto-oncogeneJAK-STAT Signaling PathwayCD117CD135Intracellular Signaling Peptides And ProteinsWnt Signaling PathwayBeta-cateninAdenomatosis Polyposis ColiTGF Beta Signaling PathwayMothers Against Decapentaplegic Homolog 2Mothers Against Decapentaplegic Homolog 4Akt/PKB Signaling PathwayAKTPTEN (gene)Hippo Signaling PathwayMerlin (protein)MAPK/ERK PathwayRas (protein)HRASC-RafNeurofibromin 1Proto-oncogene Tyrosine-protein Kinase SrcMaspinCell NucleusCell CycleCyclin-dependent Kinase 4Cyclin DCyclin EP53Retinoblastoma ProteinWT1P16 (gene)P14arfDNA RepairFanconi AnemiaBRCA1BRCA2Ubiquitin LigaseCBL (gene)Mdm2Von Hippel–Lindau Tumor SuppressorTranscription FactorAP-1 Transcription FactorC-FosC-junMycKLF6MitochondrionInhibitor Of ApoptosisSDHBSDHDBcl-2Notch SignalingStathminTemplate:Cell Cycle ProteinsTemplate Talk:Cell Cycle ProteinsCell CycleProteinCyclinCyclin ACyclin A1Cyclin A2Cyclin BCyclin B1Cyclin B2Cyclin DCyclin D1Cyclin D2Cyclin D3Cyclin ECyclin E1Cyclin E2Cyclin-dependent KinaseCyclin-dependent Kinase 1Cyclin-dependent Kinase 2Cyclin-dependent Kinase 3Cyclin-dependent Kinase 4Cyclin-dependent Kinase 5Cyclin-dependent Kinase 6Cyclin-dependent Kinase 7Cyclin-dependent Kinase 8Cyclin-dependent Kinase 9Cyclin-dependent Kinase 10CDK-activating KinaseCyclin-dependent Kinase Inhibitor ProteinCell CycleP14arfP16CDKN2BCDKN2CCDKN2DCell CycleP21CDKN1BCyclin-dependent Kinase Inhibitor 1CP53 P63 P73 FamilyP53TP63Cdk1Cdc25CDC42Cellular Apoptosis Susceptibility ProteinE2FMaturation Promoting FactorWee1CullinCUL7InterphaseG1 PhaseS PhaseG2 PhaseCell DivisionMitosisPreprophaseProphasePrometaphaseMetaphaseAnaphaseTelophaseCytokinesisCell Cycle CheckpointRestriction PointSpindle CheckpointPostreplication CheckpointApoptosisG0 PhaseMeiosisEnsembl Genome Database ProjectEnsembl Genome Database ProjectHelp:CategoryCategory:Genes On Human Chromosome 1Category:ProteinsCategory:Tumor Suppressor GenesDiscussion About Edits From This IP Address [n]A List Of Edits Made From This IP Address [y]View The Content Page [c]Discussion About The Content Page [t]Edit This Page [e]Visit The Main Page [z]Guides To Browsing WikipediaFeatured Content – The Best Of WikipediaFind Background Information On Current EventsLoad A Random Article [x]Guidance On How To Use And Edit WikipediaFind Out About WikipediaAbout The Project, What You Can Do, Where To Find ThingsA List Of Recent Changes In The Wiki [r]List Of All English Wikipedia Pages Containing Links To This Page [j]Recent Changes In Pages Linked From This Page [k]Upload Files [u]A List Of All Special Pages [q]Wikipedia:AboutWikipedia:General Disclaimer



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