Contents 1 History 2 The birth of bacteriology 3 Branches 4 Applications 5 See also 6 References 7 External links

History[edit] Avicenna hypothesized the existence of microorganisms. The existence of microorganisms was hypothesized for many centuries before their actual discovery. The existence of unseen microbiological life was postulated by Jainism which is based on Mahavira’s teachings as early as 6th century BCE.[4] Paul Dundas notes that Mahavira asserted the existence of unseen microbiological creatures living in earth, water, air and fire.[5] Jain scriptures describe nigodas which are sub-microscopic creatures living in large clusters and having a very short life, said to pervade every part of the universe, even in tissues of plants and flesh of animals.[6] The Roman Marcus Terentius Varro made references to microbes when he warned against locating a homestead in the vicinity of swamps "because there are bred certain minute creatures which cannot be seen by the eyes, which float in the air and enter the body through the mouth and nose and thereby cause serious diseases."[7] In the golden age of Islamic civilization, some scientists hypothesized the existence of microorganisms, such as Avicenna in his book The Canon of Medicine, Ibn Zuhr (also known as Avenzoar) who discovered scabies mites, and Al-Razi who gave the earliest known description of smallpox in his book The Virtuous Life (al-Hawi).[8] In 1546, Girolamo Fracastoro proposed that epidemic diseases were caused by transferable seedlike entities that could transmit infection by direct or indirect contact, or vehicle transmission.[9] Van Leeuwenhoek is often cited as the first to observe, describe, and conduct scientific experiments with microorganisms.[10] [11][12][13] In 1676, Antonie van Leeuwenhoek , who lived most of his life in Delft, Holland, observed bacteria and other microorganisms using a single-lens microscope of his own design.[14][1] He is considered a father of microbiology as he pioneered the use of simple single-lensed microscopes of his own design.[14] While Van Leeuwenhoek is often cited as the first to observe microbes, Robert Hooke made his first recorded microscopic observation, of the fruiting bodies of moulds, in 1665.[15] It has, however, been suggested that a Jesuit priest called Athanasius Kircher was the first to observe micro-organisms.[16] Kircher was among the first to design magic lanterns for projection purposes, so he must have been well acquainted with the properties of lenses.[16] He wrote "Concerning the wonderful structure of things in nature, investigated by Microscope" in 1646, stating "who would believe that vinegar and milk abound with an innumerable multitude of worms." He also noted that putrid material is full of innumerable creeping animalcules. He published his Scrutinium Pestis (Examination of the Plague) in 1658, stating correctly that the disease was caused by microbes, though what he saw was most likely red or white blood cells rather than the plague agent itself.[16]

The birth of bacteriology[edit] Innovative laboratory glassware and experimental methods developed by Louis Pasteur and other biologists contributed to the young field of bacteriology in the late 19th century. The field of bacteriology (later a subdiscipline of microbiology) was founded in the 19th century by Ferdinand Cohn, a botanist whose studies on algae and photosynthetic bacteria led him to describe several bacteria including Bacillus and Beggiatoa. Cohn was also the first to formulate a scheme for the taxonomic classification of bacteria, and to discover endospores.[17] Louis Pasteur and Robert Koch were contemporaries of Cohn, and are often considered to be the father of microbiology[16] and medical microbiology, respectively.[18] Pasteur is most famous for his series of experiments designed to disprove the then widely held theory of spontaneous generation, thereby solidifying microbiology’s identity as a biological science.[19] One of his students, Adrien Certes, is considered the founder of marine microbiology.[20] Pasteur also designed methods for food preservation (pasteurization) and vaccines against several diseases such as anthrax, fowl cholera and rabies.[1] Koch is best known for his contributions to the germ theory of disease, proving that specific diseases were caused by specific pathogenic micro-organisms. He developed a series of criteria that have become known as the Koch's postulates. Koch was one of the first scientists to focus on the isolation of bacteria in pure culture resulting in his description of several novel bacteria including Mycobacterium tuberculosis, the causative agent of tuberculosis.[1] While Pasteur and Koch are often considered the founders of microbiology, their work did not accurately reflect the true diversity of the microbial world because of their exclusive focus on micro-organisms having direct medical relevance. It was not until the late 19th century and the work of Martinus Beijerinck and Sergei Winogradsky that the true breadth of microbiology was revealed.[1] Beijerinck made two major contributions to microbiology: the discovery of viruses and the development of enrichment culture techniques.[21] While his work on the Tobacco Mosaic Virus established the basic principles of virology, it was his development of enrichment culturing that had the most immediate impact on microbiology by allowing for the cultivation of a wide range of microbes with wildly different physiologies. Winogradsky was the first to develop the concept of chemolithotrophy and to thereby reveal the essential role played by micro-organisms in geochemical processes.[22] He was responsible for the first isolation and description of both nitrifying and nitrogen-fixing bacteria.[1] French-Canadian microbiologist Felix d'Herelle co-discovered bacteriophages in 1917 and was one of the earliest applied microbiologists.[23] Joseph Lister was the first to use phenol disinfectant on the open wounds of patients.[24]

Branches[edit] Food microbiology laboratory at the Faculty of Food Technology, Latvia University of Agriculture. Main article: Branches of microbiology The branches of microbiology can be classified into pure and applied sciences.[25] Microbiology can be also classified based on taxonomy, in the cases of bacteriology, mycology, protozoology, and phycology. There is considerable overlap between the specific branches of microbiology with each other and with other disciplines, and certain aspects of these branches can extend beyond the traditional scope of microbiology[26][27]

Applications[edit] Fermenting tanks with yeast being used to brew beer While some fear microbes due to the association of some microbes with various human diseases, many microbes are also responsible for numerous beneficial processes such as industrial fermentation (e.g. the production of alcohol, vinegar and dairy products), antibiotic production and act as molecular vehicles to transfer DNA to complex organisms such as plants and animals. Scientists have also exploited their knowledge of microbes to produce biotechnologically important enzymes such as Taq polymerase, reporter genes for use in other genetic systems and novel molecular biology techniques such as the yeast two-hybrid system.[citation needed] Bacteria can be used for the industrial production of amino acids. Corynebacterium glutamicum is one of the most important bacterial species with an annual production of more than two million tons of amino acids, mainly L-glutamate and L-lysine.[28] Since some bacteria have the ability to synthesize antibiotics, they are used for medicinal purposes, such as Streptomyces to make aminoglycoside antibiotics.[29] A variety of biopolymers, such as polysaccharides, polyesters, and polyamides, are produced by microorganisms. Microorganisms are used for the biotechnological production of biopolymers with tailored properties suitable for high-value medical application such as tissue engineering and drug delivery. Microorganisms are used for the biosynthesis of xanthan, alginate, cellulose, cyanophycin, poly(gamma-glutamic acid), levan, hyaluronic acid, organic acids, oligosaccharides and polysaccharide, and polyhydroxyalkanoates.[30] Microorganisms are beneficial for microbial biodegradation or bioremediation of domestic, agricultural and industrial wastes and subsurface pollution in soils, sediments and marine environments. The ability of each microorganism to degrade toxic waste depends on the nature of each contaminant. Since sites typically have multiple pollutant types, the most effective approach to microbial biodegradation is to use a mixture of bacterial and fungal species and strains, each specific to the biodegradation of one or more types of contaminants.[31] Symbiotic microbial communities confer benefits to their human and animal hosts health including aiding digestion, producing beneficial vitamins and amino acids, and suppressing pathogenic microbes. Some benefit may be conferred by eating fermented foods, probiotics (bacteria potentially beneficial to the digestive system) or prebiotics (substances consumed to promote the growth of probiotic microorganisms).[32][33] The ways the microbiome influences human and animal health, as well as methods to influence the microbiome are active areas of research.[34] Research has suggested that microorganisms could be useful in the treatment of cancer. Various strains of non-pathogenic clostridia can infiltrate and replicate within solid tumors. Clostridial vectors can be safely administered and their potential to deliver therapeutic proteins has been demonstrated in a variety of preclinical models.[35]

See also[edit] Archaea Biosafety Microbes and Man Professional organizations American Society for Microbiology Federation of European Microbiological Societies Society for Applied Microbiology Society for General Microbiology Journals Critical Reviews in Microbiology International Journal of Systematic and Evolutionary Microbiology Journal of Bacteriology Nature Reviews Microbiology

References[edit] ^ a b c d e f Madigan M, Martinko J (editors) (2006). Brock Biology of Microorganisms (13th ed.). Pearson Education. p. 1096. ISBN 0-321-73551-X. CS1 maint: Extra text: authors list (link) ^ Nitesh RA, Ludwig W, Schleifer KH (2011). "Phylogenetic identification and in situ detection of individual microbial cells without cultivation". Microbiological Reviews. 59 (1): 143–169. PMC 239358 . PMID 7535888.  ^ Rice G (2007-03-27). "Are Viruses Alive?". Retrieved 2007-07-23.  ^ Mahavira is dated 599 BC - 527 BC. See Dundas, Paul; John Hinnels ed. (2002). The Jain. London: Routledge. ISBN 0-415-26606-8. CS1 maint: Extra text: authors list (link) p. 24 ^ Dundas, Paul (2002) p. 88 ^ Jaini, Padmanabh (1998). The Jaina Path of Purification. New Delhi: Motilal Banarsidass. p. 109. ISBN 81-208-1578-5.  ^ Marcus Terentius Varro. Varro on Agriculture 1, xii Loeb. ^ "فى الحضارة الإسلامية - ديوان العرب" [Microbiology in Islam]. (in Arabic). Retrieved 14 April 2017.  ^ Fracastoro, Girolamo (1546), De Contagione et Contagiosis Morbis transl. Wilmer Cave Wright (1930). New York: G.P. Putnam's ^ Dobell, Clifford (1932). Antony van Leeuwenhoek and His "Little Animals": being some account of the father of protozoology and bacteriology and his multifarious discoveries in these disciplines (Dover Publications ed.). New York: Harcourt, Brace and Company.  ^ Corliss, John O (1975). "Three Centuries of Protozoology: A Brief Tribute to its Founding Father, A. van Leeuwenhoek of Delft". The Journal of Protozoology. 22 (1): 3–7. doi:10.1111/j.1550-7408.1975.tb00934.x.  ^ Ford, Brian J. (1992). "From Dilettante to Diligent Experimenter: a Reappraisal of Leeuwenhoek as microscopist and investigator". Biology History. 5 (3).  ^ Toledo-Pereyra, Luis H.: The Strange Little Animals of Antony van Leeuwenhoek — Surgical Revolution, in Surgical Revolutions: A Historical and Philosophical View. (World Scientific Publishing, 2008, ISBN 978-9814329620) ^ a b Lane, Nick (6 March 2015). "The Unseen World: Reflections on Leeuwenhoek (1677) 'Concerning Little Animal'". Philos Trans R Soc Lond B Biol Sci. 370 (1666): 20140344. doi:10.1098/rstb.2014.0344. PMC 4360124 . PMID 25750239.  ^ Gest H (2005). "The remarkable vision of Robert Hooke (1635-1703): first observer of the microbial world". Perspect. Biol. Med. 48 (2): 266–72. doi:10.1353/pbm.2005.0053. PMID 15834198.  ^ a b c d Wainwright, Milton (2003). "An Alternative View of the Early History of Microbiology". Advances in Applied Microbiology. Advances in Applied Microbiology. 52: 333–55. doi:10.1016/S0065-2164(03)01013-X. ISBN 978-0-12-002654-8. PMID 12964250.  ^ Drews, G. (1999). "Ferdinand Cohn, among the Founder of Microbiology". ASM News. 65 (8): 547.  ^ Ryan, K.J.; Ray, C.G., eds. (2004). Sherris Medical Microbiology (4th ed.). McGraw Hill. ISBN 0-8385-8529-9.  ^ Bordenave, G. (2003). "Louis Pasteur (1822-1895)". Microbes Infect. 5 (6): 553–60. doi:10.1016/S1286-4579(03)00075-3. PMID 12758285.  ^ Adler, Antony; Dücker, Erik (2017-04-05). "When Pasteurian Science Went to Sea: The Birth of Marine Microbiology". Journal of the History of Biology: 1–27. doi:10.1007/s10739-017-9477-8.  ^ Johnson, J. (2001) [1998]. "Martinus Willem Beijerinck". APSnet. American Phytopathological Society. Archived from the original on 2010-06-20. Retrieved May 2, 2010.  Retrieved from Internet Archive January 12, 2014. ^ Paustian T, Roberts G (2009). "Beijerinck and Winogradsky Initiate the Field of Environmental Microbiology". Through the Microscope: A Look at All Things Small (3rd ed.). Textbook Consortia. § 1–14. Retrieved May 2, 2010.  ^ Keen, E.C. (2012). "Felix d'Herelle and Our Microbial Future". Future Microbiology. 7 (12): 1337–1339. doi:10.2217/fmb.12.115. PMID 23231482.  ^ Lister, Joseph (2010-08-01). "The Classic: On the Antiseptic Principle in the Practice of Surgery". Clinical Orthopaedics and Related Research. 468 (8): 2012–2016. doi:10.1007/s11999-010-1320-x. PMC 2895849 . PMID 20361283.  ^ Pharmaceutical Microbiology Principles and Applications. Nirali Prakashan. pp. 1.1–1.2. ISBN 978-81-85790-61-9. Retrieved 18 June 2011.  ^ "Branches of Microbiology". General MicroScience. 2017-01-13. Retrieved 2017-12-10.  ^ Brock Biology of Microorganisms (14th ed.). ISBN 978-0321897398.  ^ Burkovski A (editor). (2008). Corynebacteria: Genomics and Molecular Biology. Caister Academic Press. ISBN 1-904455-30-1. Retrieved 2016-03-25.  ^ Fourmy, Dominique; Recht, Michael I.; Blanchard, Scott C; Puglisi, Joseph D. (1996). "Structure of the A site of Escherichia coli 16S ribosomal RNA complexed with an Aminoglycoside Antibiotic" (PDF). Science. 274 (5291): 1367–1371. Bibcode:1996Sci...274.1367F. doi:10.1126/science.274.5291.1367. PMID 8910275. Retrieved 2016-04-05.  ^ Rehm BHA (editor). (2008). Microbial Production of Biopolymers and Polymer Precursors: Applications and Perspectives. Caister Academic Press. ISBN 978-1-904455-36-3. Retrieved 2016-03-25.  ^ Diaz E (editor). (2008). Microbial Biodegradation: Genomics and Molecular Biology (1st ed.). Caister Academic Press. ISBN 1-904455-17-4. Retrieved 2016-03-25.  ^ MacFarlane, GT; Cummings, JH (1999). "Probiotics and prebiotics: Can regulating the activities of intestinal bacteria benefit health?". BMJ: British Medical Journal. 318 (7189): 999–1003. doi:10.1136/bmj.318.7189.999. PMC 1115424 . PMID 10195977.  ^ Tannock GW, ed. (2005). Probiotics and Prebiotics: Scientific Aspects. Caister Academic Press. ISBN 978-1-904455-01-1. Retrieved 2016-03-25.  ^ Wenner, Melinda (30 November 2007). "Humans Carry More Bacterial Cells than Human Ones". Scientific American. Retrieved 14 April 2017.  ^ Mengesha; et al. (2009). "Clostridia in Anti-tumor Therapy". Clostridia: Molecular Biology in the Post-genomic Era. Caister Academic Press. 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