Contents 1 Bacteriophages 1.1 Fitness tradeoffs for bacteria 1.2 Lysogenic conversion 1.2.1 Bacterial survival 1.2.2 Bacterial virulence 1.2.3 Preventing lysogenic induction 2 References


Bacteriophages[edit] Bacteriophages are viruses that infect and replicate within a bacterium. Temperate phages (such as lambda phage) can reproduce using both the lytic and the lysogenic cycle. Via the lysogenic cycle, the bacteriophage's genome is not expressed and is instead integrated into the bacteria's genome to form the prophage.[3] Since the bacteriophage's genetic information is incorporated into the bacteria's genetic information as a prophage, the bacteriophage replicates passively as the bacterium divides to form daughter bacteria cells.[3] In this scenario, the daughter bacteria cells contain prophage and are known as lysogens. Lysogens can remain in the lysogenic cycle for many generations but can switch to the lytic cycle at any time via a process known as induction.[3] During induction, prophage DNA is excised from the bacterial genome and is transcribed and translated to make coat proteins for the virus and regulate lytic growth.[3] The model organism for studying lysogeny is lambda phage. Prophage integration, maintenance of lysogeny, induction, and control of phage genome excision in induction is described in detail in the lambda phage article. Fitness tradeoffs for bacteria[edit] Bacteriophages are parasitic because they infect their hosts, use bacterial machinery to replicate, and ultimately lyse the bacteria. Temperate phages can lead to both advantages and disadvantages for their hosts via the lysogenic cycle. During the lysogenic cycle, the virus genome is incorporated as prophage and a repressor prevents viral replication. Nonetheless, a temperate phage can escape repression to replicate, produce viral particles, and lyse the bacteria.[4] The temperate phage escaping repression would be a disadvantage for the bacteria. On the other hand, the prophage may transfer genes that enhance host virulence and resistance to the immune system. Also, the repressor produced by the prophage that prevents prophage genes from being expressed confers an immunity for the host bacteria from lytic infection by related viruses.[4] Lysogenic conversion[edit] In some interactions between lysogenic phages and bacteria, lysogenic conversion may occur, which can also be called phage conversion. It is when a temperate phage induces a change in the phenotype of the infected bacteria that is not part of a usual phage cycle. Changes can often involve the external membrane of the cell by making it impervious to other phages or even by increasing the pathogenic capability of the bacteria for a host. In this way, temperate bacteriophages also play a role in the spread of virulence factors, such as exotoxins and exoenzymes, amongst bacteria. This change then stays in the genome of the infected bacteria and is copied and passed down to daughter cells. Bacterial survival[edit] Lysogenic conversion has shown to enable biofilm formation in Bacillus anthracis[5] Strains of B. anthracis cured of all phage were unable to form biofilms, which are surface-adhered bacterial communities that enable bacteria to better access nutrients and survive environmental stresses.[6] In addition to biofilm formation in B. anthracis, lysogenic conversion of Bacillus subtilis, Bacillus thuringiensis, and Bacillus cereus has shown an enhanced rate or extent of sporulation.[5] Sporulation produces endospores, which are metabolically dormant forms of the bacteria that are highly resistant to temperature, ionizing radiation, desiccation, antibiotics, and disinfectants.[5] Bacterial virulence[edit] Non-virulent bacteria have also been shown to transform into highly virulent pathogens through lysogenic conversion with the virulence factors carried on the lysogenic prophage.[7] Virulence genes carried within prophages as discrete autonomous genetic elements, known as morons, confer an advantage to the bacteria that indirectly benefits the virus through enhanced lysogen survival.[5] Examples: Corynebacterium diphtheriae produces the toxin of diphtheria only when it is infected by the phage β. In this case, the gene that codes for the toxin is carried by the phage, not the bacteria.[8] Vibrio cholerae is a non-toxic strain that can become toxic, producing cholera toxin, when it is infected with the phage CTXφ. Shigella dysenteriae, which produces dysentery has toxins that fall into two major groups, Stx1 and Stx2, whose genes are considered to be part of the genome of lambdoid prophages. Streptococcus pyogenes, produce a pyrogenic exotoxin, obtained by lysogenic conversion, which causes fever and a scarlet-red rash, Scarlet Fever. Certain strains of Clostridium botulinum, which causes botulism, express botulinum toxin from phage-tranduced genes. Preventing lysogenic induction[edit] Strategies to combat certain bacterial infections by blocking prophage induction (the transition from the lysogenic to the lytic cycle) by eliminating in vivo induction agents have been proposed.[7] Reactive oxygen species (ROS), such as hydrogen peroxide, are strong oxidizing agents that can decompose into free radicals and cause DNA damage to bacteria, which leads to prophage induction.[7] One potential strategy to combat prophage induction is through the use of glutathione, a strong antioxidant that can remove free radical intermediates.[7] Another approach could be to cause an overexpression of CI repressor since prophage induction only occurs when the concentration of CI repressor is too low.[7]


References[edit] ^ a b c Campbell and Reece (2005). Biology. San Francisco: Pearson. pp. 338–339.  ^ Lodish; et al. (2008). Molecular Cell Biology. New York: W.H. Freeman. pp. 158–159.  ^ a b c d Watson; et al. (2008). Molecular Biology of the Gene. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press. pp. 784–786.  ^ a b Chen; et al. (21 June 2005). "Population Fitness and the Regulation of Escherichia coli Genes by Bacterial Viruses". PLOS Biology. 3 (7): e229. doi:10.1371/journal.pbio.0030229.  ^ a b c d Louis-Charles Fortier; et al. (23 April 2013). "Importance of prophages to evolution and virulence of bacterial pathogens". Virulence. 4 (5): 354–65. doi:10.4161/viru.24498. PMC 3714127 . PMID 23611873.  ^ Nadell; et al. (13 July 2011). "A fitness trade-off between local competition and dispersal in Vibrio cholerae biofilms". PNAS. 108: 14181–14185. doi:10.1073/pnas.1111147108. PMC 3161532 . PMID 21825170.  ^ a b c d e Keen, Eric C. (14 December 2012). "Paradigms of pathogenesis: targeting the mobile genetic elements of disease". Frontiers in Cellular and Infection Microbiology. 2: 161. doi:10.3389/fcimb.2012.00161. PMC 3522046 . PMID 23248780.  ^ Mokrousov I (January 2009). "Corynebacterium diphtheriae: genome diversity, population structure and genotyping perspectives". Infection, Genetics and Evolution. 9 (1): 1–15. doi:10.1016/j.meegid.2008.09.011. PMID 19007916.  Retrieved from "https://en.wikipedia.org/w/index.php?title=Lysogenic_cycle&oldid=820412826" Categories: BacteriophagesVirologyBacteriology


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