Contents 1 Structure 2 Function 2.1 Cycle 3 Gene and protein expression 4 Clinical significance 4.1 Embryo transfer 5 Microbiome 6 Additional images 7 See also 8 References 9 External links


Structure[edit] High magnification micrograph of decidualized endometrium due to exogenous progesterone (oral contraceptive pill). H&E stain Low magnification micrograph of decidualized endometrium. H&E stain The endometrium consists of a single layer of columnar epithelium plus the stroma on which it rests. The stroma is a layer of connective tissue that varies in thickness according to hormonal influences. Simple tubular uterine glands reach from the endometrial surface through to the base of the stroma, which also carries a rich blood supply of spiral arteries. In a woman of reproductive age, two layers of endometrium can be distinguished. These two layers occur only in endometrium lining the cavity of the uterus, not in the lining of the uterine (Fallopian) tubes:[1][2] The functional layer is adjacent to the uterine cavity. This layer is built up after the end of menstruation during the first part of the previous menstrual cycle. Proliferation is induced by estrogen (follicular phase of menstrual cycle), and later changes in this layer are engendered by progesterone from the corpus luteum (luteal phase). It is adapted to provide an optimum environment for the implantation and growth of the embryo. This layer is completely shed during menstruation. The basal layer, adjacent to the myometrium and below the functional layer, is not shed at any time during the menstrual cycle, and from it the functional layer develops. In the absence of progesterone, the arteries supplying blood to the functional layer constrict, so that cells in that layer become ischaemic and die, leading to menstruation. It is possible to identify the phase of the menstrual cycle by reference to either the ovarian cycle or the uterine cycle by observing histological differences at each phase—for example in the ovarian cycle: Phase Days Thickness Epithelium Menstrual phase 1–5 Thin Absent Follicular phase 5–14 Intermediate Columnar Luteal phase 15–27 Thick Columnar. Also visible are arcuate vessels of uterus Ischemic phase 27–28 Columnar. Also visible are arcuate vessels of uterus


Function[edit] The endometrium is the innermost glandular layer and functions as a lining for the uterus, preventing adhesions between the opposed walls of the myometrium, thereby maintaining the patency of the uterine cavity. During the menstrual cycle or estrous cycle, the endometrium grows to a thick, blood vessel-rich, glandular tissue layer. This represents an optimal environment for the implantation of a blastocyst upon its arrival in the uterus. The endometrium is central, echogenic (detectable using ultrasound scanners), and has an average thickness of 6.7 mm. During pregnancy, the glands and blood vessels in the endometrium further increase in size and number. Vascular spaces fuse and become interconnected, forming the placenta, which supplies oxygen and nutrition to the embryo and fetus. Cycle[edit] The endometrial lining undergoes cyclic regeneration. Humans and great apes display the menstrual cycle, whereas most other mammals are subject to an estrous cycle. In both cases, the endometrium initially proliferates under the influence of estrogen. However, once ovulation occurs, the ovary (specifically the corpus luteum) will produce much larger amounts of progesterone. This changes the proliferative pattern of the endometrium to a secretory lining. Eventually, the secretory lining provides a hospitable environment for one or more blastocysts. Upon fertilization, the egg may implant into the uterine wall and provide feedback to the body with human chorionic gonadotropin (HCG). HCG provides continued feedback throughout pregnancy by maintaining the corpus luteum, which will continue its role of releasing progesterone and estrogen. The endometrial lining is either reabsorbed (estrous cycle) or shed (menstrual cycle). In the latter case, the process of shedding involves the breaking down of the lining, the tearing of small connective blood vessels, and the loss of the tissue and blood that had constituted it through the vagina. The entire process occurs over a period of several days. Menstruation may be accompanied by a series of uterine contractions; these help expel the menstrual endometrium. In case of implantation, however, the endometrial lining is neither absorbed nor shed. Instead, it remains as decidua. The decidua becomes part of the placenta; it provides support and protection for the gestation. If there is inadequate stimulation of the lining, due to lack of hormones, the endometrium remains thin and inactive. In humans, this will result in amenorrhea, or the absence of a menstrual period. After menopause, the lining is often described as being atrophic. In contrast, endometrium that is chronically exposed to estrogens, but not to progesterone, may become hyperplastic. Long-term use of oral contraceptives with highly potent progestins can also induce endometrial atrophy.[4][5] In humans, the cycle of building and shedding the endometrial lining lasts an average of 28 days. The endometrium develops at different rates in different mammals. Various factors including the seasons, climate, and stress can affect its development. The endometrium itself produces certain hormones at different stages of the cycle and this affects other parts of the reproductive system.


Gene and protein expression[edit] Further information: Bioinformatics § Gene and protein expression About 20,000 protein coding genes are expressed in human cells and some 70% of these genes are expressed in the normal endometrium.[6][7] Just over 100 of these genes are more specifically expressed in the endometrium with only a handful genes being highly endometrium specific. The corresponding specific proteins are expressed in the glandular and stromal cells of the endometrial mucosa. The expression of many of these proteins vary depending on the menstrual cycle, for example the progestorone receptor and thyrotropin-releasing hormone both expressed in the proliferative phase, and PAEP expressed in the secretory phase. Other proteins such as the HOX11 protein that is required for female fertility, is expressed in endometrial stroma cells throughout the menstrual cycle. Certain specific proteins such as the estrogen receptor are also expressed in other types of female tissue types, such as the cervix, fallopian tubes, ovaries and breast.[8]


Clinical significance[edit] Chorionic tissue can result in marked endometrial changes, known as an Arias-Stella reaction, that have an appearance similar to cancer.[9] Historically, this change was diagnosed as endometrial cancer and it is important only in so far as it should not be misdiagnosed as cancer. Adenomyosis is the growth of the endometrium into the muscle layer of the uterus (the myometrium). Endometriosis is the growth of endometrial tissue outside the uterus. Endometrial hyperplasia Endometrial cancer is the most common cancer of the human female genital tract. Asherman's syndrome, also known as intrauterine adhesions occurs when the basal layer of the endometrium is damaged by instrumentation (e.g., D&C) or infection (e.g., endometrial tuberculosis) resulting in endometrial sclerosis and adhesion formation partially or completely obliterating the uterine cavity. Thin endometrium may be defined as an endometrial thickness of less than 8 mm. It usually occurs after menopause. Treatments that can improve endometrial thickness include Vitamin E, L-arginine and sildenafil citrate.[10] Gene expression profiling using cDNA microarray can be used for the diagnosis of endometrial disorders.[11] The European Menopause and Andropause Society (EMAS) released Guidelines with detailed information to assess the endometrium. [12] Embryo transfer[edit] An endometrial thickness (EMT) of less than 7 mm decreases the pregnancy rate in in vitro fertilization by an odds ratio of approximately 0.4 compared to an EMT of over 7 mm. However, such low thickness rarely occurs, and any routine use of this parameter is regarded as not justified.[13] Triple-line endometrium measuring 7mm. Observation of the endometrium by transvaginal ultrasonography is used when administering fertility medication, such as in in vitro fertilization. At the time of embryo transfer, it is favorable to have an endometrium of a thickness of between 7 and 14 mm with a triple-line configuration,[14] which means that the endometrium contains a hyperechoic (usually displayed as light) line in the middle surrounded by two more hypoechoic (darker) lines. A triple-line endometrium reflects the separation of the stratum basalis and functionalis layers, and is also observed in the periovulatory period secondary to rising estradiol levels, and disappears after ovulation.[15]


Microbiome[edit] The endometrium was once thought to be sterile. Instead, a resident, non-pathogenic, and diverse population of microorganisms are present in healthy tissue. The uterus and its tissues are not sterile.[16][17][18][19] The first studies of flora colonizing the human endometrium were published in 2015, were on special populations, and were too small from which to generalize. In one study of 58 women undergoing hysterectomy, investigators looked for 12 species of bacteria; Lactobacillus and Prevotella were the most commonly detected species and overall density was much lower than vaginal colonization. In another study of 22 infertile women undergoing fertility treatments, Lactobacillus and Flavobacterium were most prevalent, and characteristics of the flora were roughly similar in women who became pregnant and those who didn't.[3]


Additional images[edit] The initial stages of human embryogenesis Vertical section of mucous membrane of human uterus. Endometrioid adenocarcinoma from biopsy. H&E stain. Micrograph of the endometrium. Micrograph of decidualized endometrium due to exogenous progesterone. H&E stain. Micrograph of decidualized endometrium due to exogenous progesterone. H&E stain. Micrograph showing endometrial stromal condensation, a finding seen in menses.


See also[edit] endometrial regenerative cells, also known as endometrial stem cells. CYTL1, also known as cytokine-like like protein 1.


References[edit] ^ a b Blue Histology - Female Reproductive System. School of Anatomy and Human Biology — The University of Western Australia Accessed 20061228 20:35 ^ a b Guyton AC and Hall JE, eds. (2006). "Chapter 81 Female Physiology Before Pregnancy and Female Hormones". Textbook of Medical Physiology (11th ed.). Elsevier Saunders. pp. 1018ff. ISBN 9780721602400. CS1 maint: Uses editors parameter (link) ^ a b Franasiak, Jason M.; Scott, Richard T. (2015). "Reproductive tract microbiome in assisted reproductive technologies". Fertility and Sterility. 104 (6): 1364–1371. doi:10.1016/j.fertnstert.2015.10.012. ISSN 0015-0282. PMID 26597628.  ^ Deligdisch, L. (1993). "Effects of hormone therapy on the endometrium". Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 6 (1): 94–106. PMID 8426860.  ^ William's Gynecology, McGraw 2008, Chapter 8, Abnormal Uterine Bleeding ^ "The human proteome in endometrium - The Human Protein Atlas". www.proteinatlas.org. Retrieved 2017-09-25.  ^ Uhlén, Mathias; Fagerberg, Linn; Hallström, Björn M.; Lindskog, Cecilia; Oksvold, Per; Mardinoglu, Adil; Sivertsson, Åsa; Kampf, Caroline; Sjöstedt, Evelina (2015-01-23). "Tissue-based map of the human proteome". Science. 347 (6220): 1260419. doi:10.1126/science.1260419. ISSN 0036-8075. PMID 25613900.  ^ Zieba, Agata; Sjöstedt, Evelina; Olovsson, Matts; Fagerberg, Linn; Hallström, Björn M.; Oskarsson, Linda; Edlund, Karolina; Tolf, Anna; Uhlen, Mathias (2015-10-21). "The Human Endometrium-Specific Proteome Defined by Transcriptomics and Antibody-Based Profiling". OMICS: A Journal of Integrative Biology. 19 (11): 659–668. doi:10.1089/omi.2015.0115.  ^ Arias-Stella, J. (Jan 2002). "The Arias-Stella reaction: facts and fancies four decades after". Adv Anat Pathol. 9 (1): 12–23. doi:10.1097/00125480-200201000-00003. PMID 11756756.  ^ Takasaki A, Tamura H, Miwa I, Taketani T, Shimamura K, Sugino N (April 2010). "Endometrial growth and uterine blood flow: a pilot study for improving endometrial thickness in the patients with a thin endometrium". Fertil. Steril. 93 (6): 1851–8. doi:10.1016/j.fertnstert.2008.12.062. PMID 19200982.  ^ Tseng, L.; Chen, I.; Chen, M.; Yan, H.; Wang, C.; Lee, C. (2010). "Genome-based expression profiling as a single standardized microarray platform for the diagnosis of endometrial disorder: an array of 126-gene model". Fertility and Sterility. 94 (1): 114–119. doi:10.1016/j.fertnstert.2009.01.130. PMID 19328470.  ^ Dreisler E, Poulsen LG, Antonsen SL, Ceausu I, Depypere H, Erel CT, Lambrinoudaki I, Pérez-López FR, Simoncini T, Tremollieres F, Rees M, Ulrich LG (2013). "EMAS clinical guide: Assessment of the endometrium in peri and postmenopausal women". Maturita. 75 (2): 181–90. doi:10.1016/j.maturitas.2013.03.011. PMID 23619009.  ^ Kasius, A.; Smit, J. G.; Torrance, H. L.; Eijkemans, M. J. C.; Mol, B. W.; Opmeer, B. C.; Broekmans, F. J. M. (2014). "Endometrial thickness and pregnancy rates after IVF: a systematic review and meta-analysis". Human Reproduction Update. 20 (4): 530–541. doi:10.1093/humupd/dmu011. ISSN 1355-4786.  ^ Zhao, Jing; Zhang, Qiong; Li, Yanping (2012). "The effect of endometrial thickness and pattern measured by ultrasonography on pregnancy outcomes during IVF-ET cycles". Reproductive Biology and Endocrinology. 10 (1): 100. doi:10.1186/1477-7827-10-100. ISSN 1477-7827.  ^ Baerwald, A. R.; Pierson, R. A. (2004). "Endometrial development in association with ovarian follicular waves during the menstrual cycle". Ultrasound in Obstetrics and Gynecology. 24 (4): 453–460. doi:10.1002/uog.1123. ISSN 0960-7692.  ^ Perez-Muñoz, Maria Elisa; Arrieta, Marie-Claire; Ramer-Tait, Amanda E.; Walter, Jens (2017). "A critical assessment of the "sterile womb" and "in utero colonization" hypotheses: implications for research on the pioneer infant icrobiome". Microbiome. 5 (1). doi:10.1186/s40168-017-0268-4. ISSN 2049-2618.  ^ Mor, Gil; Kwon, Ja-Young (2015). "Trophoblast-microbiome interaction: a new paradigm on immune regulation". American Journal of Obstetrics and Gynecology. 213 (4): S131–S137. doi:10.1016/j.ajog.2015.06.039. ISSN 0002-9378. PMID 26428492.  ^ Yarbrough, V. L.; Winkle, S.; Herbst-Kralovetz, M. M. (2014). "Antimicrobial peptides in the female reproductive tract: a critical component of the mucosal immune barrier with physiological and clinical implications". Human Reproduction Update. 21 (3): 353–377. doi:10.1093/humupd/dmu065. ISSN 1355-4786. PMID 25547201; Access provided by the University of Pittsburgh  ^ Prince, Amanda L.; Antony, Kathleen M.; Chu, Derrick M.; Aagaard, Kjersti M. (2014). "The microbiome, parturition, and timing of birth: more questions than answers". Journal of ReproductiveImmunology. 104–105: 12–19. doi:10.1016/j.jri.2014.03.006. ISSN 0165-0378. PMC 4157949 . PMID 24793619. 


External links[edit] Anatomy figure: 43:05-15 at Human Anatomy Online, SUNY Downstate Medical Center - "The uterus, uterine tubes and ovary with associated structures." Histology image: 18902loa – Histology Learning System at Boston University - "Female Reproductive System uterus, endometrium" Swiss embryology (from UL, UB, and UF) gnidation/role02 Histology image: 20_01 at the University of Oklahoma Health Sciences Center Histology at utah.edu. Slide is proliferative phase - click forward to see secretory phase v t e Female reproductive system Internal Adnexa Ovaries Follicles corpus hemorrhagicum luteum albicans Theca of follicle externa interna Follicular antrum Follicular fluid Corona radiata Zona pellucida Membrana granulosa Perivitelline space Other Germinal epithelium Tunica albuginea cortex Cumulus oophorus Stroma Medulla Fallopian tubes Isthmus Ampulla Infundibulum Fimbria Ostium Ligaments Ovarian ligament Suspensory ligament Wolffian vestiges Gartner's duct Epoophoron Vesicular appendages of epoophoron Paroophoron Uterus Regions Body Uterine cavity Fundus Cervix External orifice Cervical canal Internal orifice Supravaginal portion Vaginal portion Uterine horns Layers Endometrium epithelium Myometrium Perimetrium Parametrium Ligaments Round ligament Broad ligament Cardinal ligament Uterosacral ligament Pubocervical ligament General Uterine glands Vagina Fossa of vestibule of vagina Vaginal fornix Hymen External Vulva Labia Mons pubis Labia majora Anterior commissure Posterior commissure Pudendal cleft Labia minora Frenulum of labia minora Frenulum of clitoris Vulval vestibule Interlabial sulci Bulb of vestibule Vaginal orifice vestibular glands/ducts Bartholin's glands/Bartholin's ducts Skene's glands/Skene's ducts Clitoris Crus of clitoris Corpus cavernosum Clitoral glans Hood Urethra Urethral crest Other G-spot Urethral sponge Perineal sponge Retrieved from "https://en.wikipedia.org/w/index.php?title=Endometrium&oldid=819969096" Categories: Mammal female reproductive systemPelvisHidden categories: CS1 maint: Uses editors parameterMedicine infobox template using GraySubject or GrayPageMedicine infobox template using Dorlands parameter


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Endometrium - Photos and All Basic Informations

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LatinMedical Subject HeadingsElsevierTerminologia AnatomicaFoundational Model Of AnatomyAnatomical TerminologyEpitheliumMucous MembraneMammalUterusMenstrual CycleEstrous CyclePregnancyBlood VesselPlacentaOxygenEmbryoFetusUterine MicrobiomeEnlargeMicrographDecidualizationProgesteroneOral Contraceptive PillH&E StainEnlargeColumnar EpitheliumStroma (animal Tissue)Stroma (animal Tissue)Connective TissueHormonalGlandsSpiral ArteryMenstrual CycleEstrogenCorpus LuteumEmbryoMenstruationMyometriumIschaemicMenstruationMenstrual CycleMenstrual CycleFollicular PhaseLuteal PhaseArcuate Vessels Of UterusMyometriumUterineMenstrual CycleEstrous CycleImplantation (human Embryo)BlastocystPregnancyBlood VesselPlacentaOxygenEmbryoFetusGreat ApesMenstrual CycleEstrous CycleEstrogenOvulationProgesteroneHuman Chorionic GonadotropinVaginaDeciduaAmenorrheaMenopauseHyperplasticOral ContraceptivesProgestinAtrophyHormoneReproductive SystemBioinformaticsProgesterone ReceptorThyrotropin-releasing HormonePAEPHOXA11Estrogen Receptor AlphaCervixFallopian TubeOvaryBreastChorionic TissueArias-Stella ReactionCancerEndometrial CancerAdenomyosisMyometriumEndometriosisEndometrial HyperplasiaEndometrial CancerCancerAsherman's SyndromeAdhesionsDilation And CurettageTuberculosisMenopauseVitamin EL-arginineSildenafil CitrateGene Expression ProfilingCDNA MicroarrayEuropean Menopause And Andropause SocietyIn Vitro FertilizationOdds RatioEnlargeTransvaginal UltrasonographyFertility MedicationIn Vitro FertilizationEmbryo TransferMillimeterHyperechoicHypoechoicEstradiolAsepsisNonpathogenic OrganismsMicroorganismsTissue (biology)Sterilization (microbiology)Human MicrobiomeAssisted Reproductive TechnologyHuman EmbryogenesisProgesteroneH&E StainMensesCYTL1International Standard Book NumberSpecial:BookSources/9780721602400Category:CS1 Maint: Uses Editors ParameterDigital Object IdentifierInternational Standard Serial NumberPubMed IdentifierPubMed IdentifierDigital Object IdentifierInternational 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