Contents 1 E2F family 2 Genes 3 Structure 4 Role in the cell cycle 5 E2F/pRb complexes 5.1 Activators: E2F1, E2F2, E2F3a 5.2 Inhibitors: E2F3b, E2F4, E2F5, E2F6, E2F7, E2F8 6 Transcriptional targets 7 See also 8 References 9 External links


E2F family[edit] Schematic diagram of the amino acid sequences of E2F family members (N-terminus to the left, C-terminus to the right) highlighting the relative locations of functional domains within each member: Family members Legend cyc A - Cyclin A binding domain DNA - DNA-binding domain DP1,2 - domain for dimerization with DP1, 2 TA - transcriptional activation domain PB - pocket protein binding domain


Genes[edit] Homo sapiens E2F1 mRNA or E2F1 protein sequences from NCBI protein and nucleotide database.


Structure[edit] X-ray crystallographic analysis has shown that the E2F family of transcription factors has a fold similar to the winged-helix DNA-binding motif.[1]


Role in the cell cycle[edit] Overview of signal transduction pathways involved in apoptosis. E2F family members play a major role during the G1/S transition in mammalian and plant cell cycle (see KEGG cell cycle pathway). DNA microarray analysis reveals unique sets of target promoters among E2F family members suggesting that each protein has a unique role in the cell cycle.[2] Among E2F transcriptional targets are cyclins, CDKs, checkpoints regulators, DNA repair and replication proteins. Nonetheless, there is a great deal of redundancy among the family members. Mouse embryos lacking E2F1, E2F2, and one of the E2F3 isoforms, can develop normally when either E2F3a or E2F3b, is expressed.[3] The E2F family is generally split by function into two groups: transcription activators and repressors. Activators such as E2F1, E2F2, E2F3a promote and help carryout the cell cycle, while repressors inhibit the cell cycle. Yet, both sets of E2F have similar domains. E2F1-6 have DP1,2 heterodimerization domain which allows them to bind to DP1 or DP2, proteins distantly related to E2F. Binding with DP1,2 provides a second DNA binding site, increasing E2F binding stability.[4] Most E2F have a pocket protein binding domain. Pocket proteins such as pRB and related proteins p107 and p130, can bind to E2F when hypophosphorylated. In activators, E2F binding with pRB has been shown to mask the transactivation domain responsible for transcription activation.[5] In repressors E2F4 and E2F5, pocket protein binding (more often p107 and p130 than pRB) mediates recruitment of repression complexes to silence target genes.[6] E2F6, E2F7, and E2F8 do not have pocket protein binding sites and their mechanism for gene silencing is unclear. Cdk4(6)/cyclin D and cdk2/cyclin E phosphorylate pRB and related pocket proteins allowing them to disassociate from E2F. Activator E2F proteins can then transcribe S phase promoting genes. In REF52 cells, overexpression of activator E2F1 is able to push quiescent cells into S phase.[7] While repressors E2F4 and 5 do not alter cell proliferation, they mediate G1 arrest.[2] E2F activator levels are cyclic, with maximal expression during G1/S. In contrast, E2F repressors stay constant, especially since they are often expressed in quiescent cells. Specifically, E2F5 is only expressed in terminally differentiated cells in mice.[2] The balance between repressor and activator E2F regulate cell cycle progression. When activator E2F family proteins are knocked out, repressors become active to inhibit E2F target genes.[8]


E2F/pRb complexes[edit] The Rb tumor suppressor protein (pRb) binds to the E2F1 transcription factor preventing it from interacting with the cell's transcription machinery. In the absence of pRb, E2F1 (along with its binding partner DP1) mediates the trans-activation of E2F1 target genes that facilitate the G1/S transition and S-phase. E2F targets genes that encode proteins involved in DNA replication (for example DNA polymerase, thymidine kinase, dihydrofolate reductase and cdc6), and chromosomal replication (replication origin-binding protein HsOrc1 and MCM5). When cells are not proliferating, E2F DNA binding sites contribute to transcriptional repression. In vivo footprinting experiments obtained on Cdc2 and B-myb promoters demonstrated E2F DNA binding site occupation during G0 and early G1, when E2F is in transcriptional repressive complexes with the pocket proteins. pRb is one of the targets of the oncogenic human papilloma virus protein E7, and human adenovirus protein E1A. By binding to pRB, they stop the regulation of E2F transcription factors and drive the cell cycle to enable virus genome replication. Activators: E2F1, E2F2, E2F3a[edit] Activators are maximally expressed late in G1 and can be found in association with E2F regulated promoters during the G1/S transition. The activation of E2F-3a genes follows upon the growth factor stimulation and the subsequent phosphorylation of the E2F inhibitor retinoblastoma protein, pRB. The phosphorylation of pRB is initiated by cyclin D/cdk4, cdk6 complex and continued by cyclin E/cdk2. Cyclin D/cdk4,6 itself is activated by the MAPK signaling pathway. When bound to E2F-3a, pRb can directly repress E2F-3a target genes by recruiting chromatin remodeling complexes and histone modifying activities (e.g. histone deacetylase, HDAC) to the promoter. Inhibitors: E2F3b, E2F4, E2F5, E2F6, E2F7, E2F8[edit] E2F3b, E2F4, E2F5 are expressed in quiescent cells and can be found associated with E2F-binding elements on E2F-target promoters during G0-phase. E2F-4 and 5 preferentially bind to p107/p130. E2F-6 acts as a transcriptional repressor, but through a distinct, pocket protein independent manner. E2F-6 mediates repression by direct binding to polycomb-group proteins or via the formation of a large multimeric complex containing Mga and Max proteins. The repressor genes E2F7/E2F8, located on chromosome 7, are transcription factors responsible for protein coding cell cycle regulation. Together, they are essential for the development of an intact, organized, and functional placental structure during embryonic development. While the specific molecular pathways remain unknown, researchers have used placental and fetal lineage specific cre mice to determine the functions of the synergistic E2F7 and E2F8 genes. Knockout mice, deplete of E2F7 and E2F8, result in abnormal trophoblastic proliferation accompanied by advanced cellular apoptosis. Phenotypically, the placenta presents with disruptions in cellular architecture to include large clusters of undifferentiated trophoblastic cells, which have failed to invade the maternal decidua.[9] E2F7 and E2F8 proteins can function as repressors independently of DP interaction. They are unique in having a duplicated conserved E2F-like DNA-binding domain and in lacking a DP1,2-dimerization domain. They also appear to play a role in angiogenesis through the activation of vascular endothelial growth factor A. Using zebra fish, severe vascular defects of the head and somatic vessels were discovered when animals were deplete of E2F7 and E2F8 [10] Antagonized by E2F3a, a transcriptional program has been discovered that functions through the coordination of multiple genes in the E2F family in order to ensure proper development of the placenta .


Transcriptional targets[edit] Cell cycle: CCNA1,2, CCND1,2, CDK2, MYB, E2F1,2,3, TFDP1, CDC25A Negative regulators: E2F7, RB1, TP107, TP21 Checkpoints: TP53, BRCA1,2, BUB1 Apoptosis: TP73, APAF1, CASP3,7,8, MAP3K5,14 Nucleotide synthesis: thymidine kinase (tk), thymidylate synthase (ts), DHFR DNA repair: BARD1, RAD51, UNG1,2, FANCA, FANCC, FANCJ DNA replication: PCNA, histone H2A, DNA pol α {\displaystyle \alpha } and δ {\displaystyle \delta } , RPA1,2,3, CDC6, MCM2,3,4,5,6,7 [11] [12] [13] [14] [15] [16]


See also[edit] Transcription factor DP Type 3c (Pancreatogenic) Diabetes


References[edit] ^ Zheng N, Fraenkel E, Pabo CO, Pavletich NP (1999). "Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP". Genes Dev. 13 (6): 666–74. doi:10.1101/gad.13.6.666. PMC 316551 . PMID 10090723.  ^ a b c Gaubatz, S.F.; Lindeman, G.J.; Ishida, S.; Jakoi, L.; Nevins, J.R.; Livingston, D.M.; Rempel, R.E. (2000). "E2F4 and E2F5 Play an Essential Role in Pocket Protein–Mediated G1 Control". Molecular Cell. 6 (3): 729–735. doi:10.1016/S1097-2765(00)00071-X. PMID 11030352.  ^ Tsai, S.; Opavsky, R.; Sharma, N.; Wu, L.; Naidu, S.; Nolan, E.; Feria-Arias, E.; Timmers, C.; et al. (2008). "Mouse development with a single E2F activator". Nature. 454 (7208): 1137–1141. doi:10.1038/nature07066. PMID 18594513.  ^ Sozzani, R.; Maggio, C.; Varotto, S.; Canova, S.; Bergounioux, C.; Albani, D.; Cella, F. (2006). "Interplay between Arabidopsis Activating Factors E2Fb and E2Fa in Cell Cycle Progression and Development". Plant Physiology. 140 (4): 1355–1366. doi:10.1104/pp.106.077990. PMC 1435807 . PMID 16514015.  ^ Maiti, B.; Li, J.; Bruin, A.D.; Gordon, F.; Timmers, C.; Opavsky, R.; Patil, K.; Tuttle, J.; et al. (2005). "Cloning and Characterization of Mouse E2F8, a Novel Mammalian E2F Family Member Capable of Blocking Cellular Proliferation". The Journal of Biological Chemistry. 280 (18): 18211–18220. doi:10.1074/jbc.M501410200. PMID 15722552.  ^ Chen, H.; Tsai, S.; Leone, G. (2009). "Emerging roles of E2Fs in cancer: an exit from cell cycle control". Nature Reviews Cancer. 9 (11): 785–797. doi:10.1038/nrc2696. PMID 19851314.  ^ Johnson, G.; Schwarz, J.K.; Cress, W.D.; Nevins, J.R. (1993). "Expression of transcription factor E2F1 induces quiescent cells to enter S phase". Nature. 365 (6444): 349–352. doi:10.1038/365349a0. PMID 8377827.  ^ Timmers, C.; Sharma, N.; Wu, L.; Wu, J.; Orringer, D.; Trikha, P.; Saavedra, G.; Leone, P.; et al. (2007). "E2f1, E2f2, and E2f3 Control E2F Target Expression and Cellular Proliferation via a p53-Dependent Negative Feedback Loop". Molecular and Cellular Biology. 27 (1): 65–78. doi:10.1128/MCB.02147-06. PMC 1800646 . PMID 17167174.  ^ Ouseph, M., Li, J., Chen, H., Pecot, T., Wensel, P., Thompson, J., Comstock, G., Chokshi, V., Byrne, M., Forde, B., Chong, J., Huang, K., Machiraju, R., Bruin, A., and Leone, G. "Atypical E2F Repressors and Activators Coordinate Placental Development". Developmental Cell 22, 849-862, April 17, 2012. ^ Weijts, B., Bakker, W., Cornelissen, P., Liang, K., Schaftenaar, F., Westendorp, B., De Wolf, C., Paciejewska, M., Scheele, C., Kent, L., Leone, G., Schulte-Merker, S., and Bruin, A. "E2F7 and E2F8 Promote Angiogenesis Through Transcriptional Activation of VEGFA in Cooperation with HIF-1. The EMBO Journal (2012) 31, 3871-3884. ^ Cobrinik D (2005). "Pocket proteins and cell cycle control". Oncogene. 24 (17): 2796–809. doi:10.1038/sj.onc.1208619. PMID 15838516.  ^ Maiti B, Li J, de Bruin A, Gordon F, Timmers C, Opavsky R, Patil K, Tuttle J, Cleghorn W, Leone G (2005). "Cloning and characterization of mouse E2F8, a novel mammalian E2F family member capable of blocking cellular proliferation". J. Biol. Chem. 280 (18): 18211–20. doi:10.1074/jbc.M501410200. PMID 15722552.  ^ Ogawa H, Ishiguro K, Gaubatz S, Livingston DM, Nakatani Y (2002). "A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells". Science. 296 (5570): 1132–6. doi:10.1126/science.1069861. PMID 12004135.  ^ Tommasi S, Pfeifer GP (1995). "In vivo structure of the human cdc2 promoter: release of a p130-E2F-4 complex from sequences immediately upstream of the transcription initiation site coincides with induction of cdc2 expression" (abstract). Mol. Cell. Biol. 15 (12): 6901–13. PMC 230945 . PMID 8524257.  ^ Zwicker J, Liu N, Engeland K, Lucibello FC, Müller R (1996). "Cell cycle regulation of E2F site occupation in vivo". Science. 271 (5255): 1595–7. doi:10.1126/science.271.5255.1595. PMID 8599118.  ^ Tategu M, Arauchi T, Tanaka R, Nakagawa H, Yoshida K (2007). "Systems Biology-Based Identifi cation of Crosstalk between E2F Transcription Factors and the Fanconi Anemia Pathway". Gene Regulation and Systems Biology. 1 (1): 1–7. 


External links[edit] E2F Transcription Factors at the US National Library of Medicine Medical Subject Headings (MeSH) Drosophila E2F transcription factor - The Interactive Fly Drosophila E2F transcription factor 2 - The Interactive Fly v t e Transcription factors and intracellular receptors (1) Basic domains (1.1) Basic leucine zipper (bZIP) Activating transcription factor AATF 1 2 3 4 5 6 7 AP-1 c-Fos FOSB FOSL1 FOSL2 JDP2 c-Jun JUNB JunD BACH 1 2 BATF BLZF1 C/EBP α β γ δ ε ζ CREB 1 3 L1 CREM DBP DDIT3 GABPA GCN4 HLF MAF B F G K NFE 2 L1 L2 L3 NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix-loop-helix (bHLH) ATOH1 AhR AHRR ARNT ASCL1 BHLH 2 3 9 ARNTL ARNTL ARNTL2 CLOCK EPAS1 FIGLA HAND 1 2 HES 5 6 HEY 1 2 L HES1 HIF 1A 3A ID 1 2 3 4 LYL1 MESP2 MXD4 MYCL1 MYCN Myogenic regulatory factors MyoD Myogenin MYF5 MYF6 Neurogenins 1 2 3 NeuroD 1 2 NPAS 1 2 3 OLIG 1 2 Pho4 Scleraxis SIM 1 2 TAL 1 2 Twist USF1 (1.3) bHLH-ZIP AP-4 MAX MXD3 MITF MNT MLX MXI1 Myc SREBP 1 2 (1.4) NF-1 NFI A B C X SMAD R-SMAD 1 2 3 5 9 I-SMAD 6 7 4) (1.5) RF-X RFX 1 2 3 4 5 6 ANK (1.6) Basic helix-span-helix (bHSH) AP-2 α β γ δ ε (2) Zinc finger DNA-binding domains (2.1) Nuclear receptor (Cys4) subfamily 1 Thyroid hormone α β CAR FXR LXR α β PPAR α β/δ γ PXR RAR α β γ ROR α β γ Rev-ErbA α β VDR subfamily 2 COUP-TF (I II Ear-2 HNF4 α γ PNR RXR α β γ Testicular receptor 2 4 TLX subfamily 3 Steroid hormone Androgen Estrogen α β Glucocorticoid Mineralocorticoid Progesterone Estrogen related α β γ subfamily 4 NUR NGFIB NOR1 NURR1 subfamily 5 LRH-1 SF1 subfamily 6 GCNF subfamily 0 DAX1 SHP (2.2) Other Cys4 GATA 1 2 3 4 5 6 MTA 1 2 3 TRPS1 (2.3) Cys2His2 General transcription factors TFIIA TFIIB TFIID TFIIE 1 2 TFIIF 1 2 TFIIH 1 2 4 2I 3A 3C1 3C2 ATBF1 BCL 6 11A 11B CTCF E4F1 EGR 1 2 3 4 ERV3 GFI1 GLI-Krüppel family 1 2 3 REST S1 S2 YY1 HIC 1 2 HIVEP 1 2 3 IKZF 1 2 3 ILF 2 3 KLF 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 17 MTF1 MYT1 OSR1 PRDM9 SALL 1 2 3 4 SP 1 2 4 7 8 TSHZ3 WT1 Zbtb7 7A 7B ZBTB 11 16 17 20 32 33 40 zinc finger 3 7 9 10 19 22 24 33B 34 35 41 43 44 51 74 143 146 148 165 202 217 219 238 239 259 267 268 281 295 300 318 330 346 350 365 366 384 423 451 452 471 593 638 644 649 655 (2.4) Cys6 HIVEP1 (2.5) Alternating composition AIRE DIDO1 GRLF1 ING 1 2 4 JARID 1A 1B 1C 1D 2 JMJD1B (2.6) WRKY WRKY (3) Helix-turn-helix domains (3.1) Homeodomain ARX CDX 1 2 CRX CUTL1 DBX 1 2 DLX 3 4 5 EMX 1 2 EN 1 2 FHL 1 2 3 HESX1 HHEX HLX Homeobox A1 A2 A3 A4 A5 A7 A9 A10 A11 A13 B1 B2 B3 B4 B5 B6 B7 B8 B9 B13 C4 C5 C6 C8 C9 C10 C11 C12 C13 D1 D3 D4 D8 D9 D10 D11 D12 D13 HOPX IRX 1 2 3 4 5 6 MKX LMX 1A 1B MEIS 1 2 MEOX2 MNX1 MSX 1 2 NANOG NKX 2-1 2-2 2-3 2-5 3-1 3-2 6-1 6-2 NOBOX PBX 1 2 3 PHF 1 3 6 8 10 16 17 20 21A PHOX 2A 2B PITX 1 2 3 POU domain PIT-1 BRN-3: A B C Octamer transcription factor: 1 2 3/4 6 7 11 OTX 1 2 PDX1 SATB2 SHOX2 SIX 1 2 3 4 5 VAX1 ZEB 1 2 (3.2) Paired box PAX 1 2 3 4 5 6 7 8 9 PRRX 1 2 RAX (3.3) Fork head / winged helix E2F 1 2 3 4 5 FOX proteins A1 A2 A3 C1 C2 D3 D4 E1 E3 F1 G1 H1 I1 J1 J2 K1 K2 L2 M1 N1 N3 O1 O3 O4 P1 P2 P3 P4 (3.4) Heat shock factors HSF 1 2 4 (3.5) Tryptophan clusters ELF 2 4 5 EGF ELK 1 3 4 ERF ETS 1 2 ERG SPIB ETV 1 4 5 6 FLI1 Interferon regulatory factors 1 2 3 4 5 6 7 8 MYB MYBL2 (3.6) TEA domain transcriptional enhancer factor 1 2 3 4 (4) β-Scaffold factors with minor groove contacts (4.1) Rel homology region NF-κB NFKB1 NFKB2 REL RELA RELB NFAT C1 C2 C3 C4 5 (4.2) STAT STAT 1 2 3 4 5 6 (4.3) p53 p53 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF TP63 (4.4) MADS box Mef2 A B C D SRF (4.6) TATA-binding proteins TBP TBPL1 (4.7) High-mobility group BBX HMGB 1 2 3 4 HMGN 1 2 3 4 HNF 1A 1B LEF1 SOX 1 2 3 4 5 6 8 9 10 11 12 13 14 15 18 21 SRY SSRP1 TCF 3 4 TOX 1 2 3 4 (4.9) Grainyhead TFCP2 (4.10) Cold-shock domain CSDA YBX1 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1 2 HBP1 (0.3) Pocket domain Rb RBL1 RBL2 (0.5) AP-2/EREBP-related factors Apetala 2 EREBP B3 (0.6) Miscellaneous ARID 1A 1B 2 3A 3B 4A CAP IFI 16 35 MLL 2 3 T1 MNDA NFY A B C Rho/Sigma see also transcription factor/coregulator deficiencies v t e Cell cycle proteins Cyclin A (A1, A2) B (B1, B2, B3) D (D1, D2, D3) E (E1, E2) CDK 1 2 3 4 5 6 7 8 9 10 CDK-activating kinase CDK inhibitor INK4a/ARF (p14arf/p16, p15, p18, p19) cip/kip (p21, p27, p57) P53 p63 p73 family p53 p63 p73 Other Cdc2 Cdc25 Cdc42 Cellular apoptosis susceptibility protein E2F Maturation promoting factor Wee Cullin (CUL7) Phases and checkpoints Interphase G1 phase S phase G2 phase M phase Mitosis (Preprophase Prophase Prometaphase Metaphase Anaphase Telophase) Cytokinesis Cell cycle checkpoints Restriction point Spindle checkpoint Postreplication checkpoint Other cellular phases Apoptosis G0 phase Meiosis Retrieved from "https://en.wikipedia.org/w/index.php?title=E2F&oldid=798099306" Categories: Cell cycleTranscription factors


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E2F - Photos and All Basic Informations

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Transcription FactorEukaryotesCell CycleMammalBinding SitePromoter (biology)Peptide SequenceN-terminusC-terminusProtein DomainCyclin ATFDP1TFDP2National Center For Biotechnology InformationX-ray CrystallographyProtein StructureWinged-helix Transcription FactorsDNA-binding DomainEnlargeApoptosisCell CycleDNA MicroarrayCyclinCyclin-dependent KinaseDNA RepairPocket Protein FamilyRetinoblastoma ProteinRetinoblastoma ProteinDNA PolymeraseThymidine KinaseDihydrofolate ReductaseCdc6MCM5Cdc2Human Papilloma VirusAdenovirusGrowth FactorPhosphorylationRetinoblastoma ProteinPhosphorylationCyclin DCdk4Cdk6MAPK Signaling PathwayHDACPolycomb-group ProteinsCyclin-dependent KinaseRetinoblastoma ProteinTP53BRCA1CaspaseThymidine KinaseDihydrofolate ReductasePCNAHistoneDNA PolymeraseTranscription Factor DPType 3c (Pancreatogenic) DiabetesDigital Object IdentifierPubMed CentralPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed CentralPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed CentralPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierPubMed CentralPubMed IdentifierDigital Object IdentifierPubMed IdentifierMedical Subject HeadingsTemplate:Transcription Factors And Intracellular ReceptorsTemplate Talk:Transcription Factors And Intracellular ReceptorsTranscription FactorIntracellular ReceptorLeucine ZipperBZIP DomainActivating Transcription FactorApoptosis-antagonizing Transcription FactorATF1Activating Transcription Factor 2ATF3ATF4ATF5ATF6ATF7AP-1 Transcription FactorC-FosFOSBFOSL1FOSL2Jun Dimerization ProteinC-junJUNBJunDBACH1BACH2BATF (gene)BLZF1Ccaat-enhancer-binding ProteinsCEBPACEBPBCEBPGCEBPDCEBPECCAAT/enhancer Binding Protein ZetaCREBCREB1CREB3CREBL1CAMP Responsive Element ModulatorDBP (gene)DNA Damage-inducible Transcript 3GABPAGcn4HLF (gene)MAF (gene)MAFB (gene)MAFF (gene)MAFGMAFKNFE2NFE2L1NFE2L2NFE2L3NFIL3NRL (gene)NRF1NFE2L2NFE2L3XBP1Basic Helix-loop-helixATOH1Aryl Hydrocarbon ReceptorAryl Hydrocarbon Receptor RepressorAryl Hydrocarbon Receptor Nuclear TranslocatorASCL1BHLHB2BHLHB3BHLHA9ARNTLARNTLARNTL2CLOCKEPAS1FIGLAHAND1HAND2HES5HES6HEY1HEY2HEYLHES1Hypoxia-inducible FactorsHIF1AHIF3AID1ID2ID3 (gene)ID4LYL1MESP2MXD4MYCL1N-MycMyogenic Regulatory FactorsMyoDMyogeninMYF5MYF6NeurogeninsNEUROG1NEUROG2NEUROG3NeuroDNEUROD1NEUROD2NPAS1NPAS2NPAS3OLIG1OLIG2Pho4ScleraxisSIM1SIM2TAL1TAL2Twist Transcription FactorUSF1Basic Helix-loop-helix Leucine Zipper Transcription FactorsTFAP4MAX (gene)MXD3Microphthalmia-associated Transcription FactorMNT (gene)MLX (gene)MXI1MycSterol Regulatory Element-binding ProteinSREBF1SREBF2Nuclear Factor INFIANFIB (gene)NFIC (gene)NFIXSMAD (protein)R-SMADMothers Against Decapentaplegic Homolog 1Mothers Against Decapentaplegic Homolog 2Mothers Against Decapentaplegic Homolog 3Mothers Against Decapentaplegic Homolog 5Mothers Against Decapentaplegic Homolog 9I-SMADMothers Against Decapentaplegic Homolog 6Mothers Against Decapentaplegic Homolog 7Mothers Against Decapentaplegic Homolog 4RFX1RFX2RFX3RFX4RFX5RFX6RFXANKActivating Protein 2TFAP2ATFAP2BTFAP2CTFAP2DTFAP2EZinc FingerNuclear ReceptorThyroid Hormone ReceptorThyroid Hormone Receptor AlphaThyroid Hormone Receptor BetaConstitutive Androstane ReceptorFarnesoid X ReceptorLiver X ReceptorLiver X Receptor AlphaLiver X Receptor BetaPeroxisome Proliferator-activated ReceptorPeroxisome Proliferator-activated Receptor AlphaPeroxisome Proliferator-activated Receptor DeltaPeroxisome Proliferator-activated Receptor GammaPregnane X ReceptorRetinoic Acid ReceptorRetinoic Acid Receptor AlphaRetinoic Acid Receptor BetaRetinoic Acid Receptor GammaRAR-related Orphan ReceptorRAR-related Orphan Receptor AlphaRAR-related Orphan Receptor BetaRAR-related Orphan Receptor GammaRev-ErbARev-ErbA AlphaRev-ErbA BetaCalcitriol ReceptorChicken Ovalbumin Upstream Promoter-transcription FactorCOUP-TFICOUP-TFIIV-erbA-related GeneHepatocyte Nuclear Factor 4Hepatocyte Nuclear Factor 4 AlphaHepatocyte Nuclear Factor 4 GammaPhotoreceptor Cell-specific Nuclear ReceptorRetinoid X ReceptorRetinoid X Receptor AlphaRetinoid X Receptor BetaRetinoid X Receptor GammaTesticular ReceptorTesticular Receptor 2Testicular Receptor 4TLXSteroid Hormone ReceptorAndrogen ReceptorEstrogen ReceptorEstrogen Receptor AlphaEstrogen Receptor BetaGlucocorticoid ReceptorMineralocorticoid ReceptorProgesterone ReceptorEstrogen-related ReceptorEstrogen-related Receptor AlphaEstrogen-related Receptor BetaEstrogen-related Receptor GammaNur (biology)Nerve Growth Factor IBNeuron-derived Orphan Receptor 1Nuclear Receptor Related-1 ProteinLiver Receptor Homolog-1Steroidogenic Factor 1Germ Cell Nuclear FactorDAX1Small Heterodimer PartnerGATA Transcription FactorGATA1GATA2GATA3GATA4GATA5GATA6MTA1MTA2MTA3Tricho-rhino-phalangeal Syndrome Type 1General Transcription FactorTranscription Factor II ATranscription Factor II BTranscription Factor II DTranscription Factor II EGTF2E1GTF2E2Transcription Factor II FGTF2F1GTF2F2Transcription Factor II HGTF2H1GTF2H2GTF2H4GTF2IGTF3AGTF3C1GTF3C2ATBF1B-cell CLL/lymphomaBCL6BCL11ABCL11BCTCFE4F1Early Growth Response ProteinsEGR1EGR2EGR3EGR4ERV3GFI1Kruppel-like FactorsGLI1GLI2GLI3RE1-silencing Transcription FactorGLIS1GLIS2YY1HIC1HIC2HIVEP1HIVEP2HIVEP3IKZF1IKZF2IKZF3ILF2ILF3Kruppel-like FactorsKLF1KLF2KLF3KLF4KLF5KLF6KLF7KLF8KLF9KLF10KLF11KLF12KLF13KLF14KLF15KLF17MTF1MYT1OSR1PRDM9SALL1SALL2SALL3SALL4Sp1 Transcription FactorSP2 (gene)SP4 (gene)Sp7 Transcription FactorSp8 Transcription FactorTSHZ3WT1Zbtb7ZBTB7AZBTB7BZBTB11Zinc Finger And BTB Domain-containing Protein 16ZBTB17ZBTB20ZBTB32ZBTB33ZBTB40ZNF3ZNF7CNBPZNF10ZNF19ZNF22ZNF24ZNF33BZNF34ZNF35ZNF41ZNF43ZNF44BCL6ZNF74ZNF143ZNF146ZNF148Zinc Finger Protein 165ZNF202ZNF217ZNF219ZNF238ZNF239ZNF259ZNF267EGR1ZNF281ZNF295ZNF300ZNF318ZNF330ZNF346ZNF350ZNF365ZNF366ZNF384ZNF423ZNF451ZNF452ZNF471ZNF593ZNF638ZNF644ZNF649ZNF655HIVEP1Autoimmune RegulatorDIDO1GRLF1ING1ING2ING4KDM5AKDM5BKDM5CKDM5DJARID2KDM3BWRKY Protein DomainHelix-turn-helixHomeodomain FoldAristaless Related HomeoboxCDX1CDX2CRX (gene)CUTL1DBX1DBX2DLX Gene FamilyDLX3 (gene)DLX4DLX5EMX HomeogeneEMX1EMX2EN1 (gene)EN2 (gene)FHL1FHL2FHL3HESX1HHEXHLX (gene)HomeoboxHomeobox A1HOXA2HOXA3HOXA4HOXA5HOXA7HOXA9Homeobox A10HOXA11HOXA13HOXB1HOXB2HOXB3HOXB4HOXB5HOXB6HOXB7HOXB8HOXB9HOXB13HOXC4HOXC5HOXC6HOXC8HOXC9HOXC10HOXC11HOXC12HOXC13HOXD1HOXD3HOXD4HOXD8HOXD9HOXD10HOXD11HOXD12HOXD13HOPXIroquois Homeobox FactorIRX1IRX2IRX3IRX4IRX5IRX6MKXLMX1ALMX1BMEIS1MEIS2MEOX2MNX1MSX1Msh Homeobox 2Homeobox Protein NANOGNKX-homeodomain FactorNK2 Homeobox 1NKX2-2NKX2-3Homeobox Protein Nkx-2.5NKX3-1NKX3-2NKX6-1NKX6-2NOBOXPBX1PBX2PBX3PHF1PHF3PHF6PHF8PHF10PHF16PHF17PHF20PHF21APHOX2APHOX2BPITX1PITX2PITX3POU DomainPituitary-specific Positive Transcription Factor 1BRN-3POU4F1POU4F2POU4F3Octamer Transcription FactorPOU2F1Oct-2Oct-4POU3F1POU3F2POU3F4OTX1Orthodenticle Homeobox 2PDX1SATB2SHOX2SIX1SIX2SIX3SIX4SIX5VAX1ZEB1ZEB2Pax GenesPAX1PAX2PAX3PAX4PAX5PAX6PAX7PAX8PAX9PRRX1PRRX2Retinal Homeobox Protein RxFOX ProteinsWinged-helix Transcription FactorsE2F1E2F2E2F3E2F4E2F5FOX ProteinsFOXA1FOXA2FOXA3Forkhead Box C1FOXC2FOXD3FOXD4FOXE1FOXE3FOXF1FOXG1FOXH1FOXI1FOXJ1FOXJ2FOXK1FOXK2Forkhead Box L2FOXM1FOXN1FOXN3FOXO1FOXO3FOXO4FOXP1FOXP2FOXP3FOXP4Heat Shock FactorHeat Shock FactorHSF1HSF2HSF4ELF2ELF4ELF5EHF (gene)ELK1ELK3ELK4ERF (gene)ETS Transcription Factor FamilyETS1ETS2ERG (gene)SPIBETV1ETV4ERM Transcription FactorETV6FLI1Interferon Regulatory FactorsIRF1IRF2IRF3IRF4IRF5IRF6IRF7IRF8MYB (gene)MYBL2TEAD1TEAD2TEAD3TEAD4Rel Homology DomainNF-κBNFKB1NFKB2RELRELARELBNFATNFATC1NFATC2NFATC3NFATC4NFAT5STAT ProteinSTAT ProteinSTAT1STAT2STAT3STAT4STAT5STAT6P53T-boxTBX1TBX2TBX3TBX5 (gene)TBX19TBX21TBX22TBR1EomesoderminBrachyuryMyelin Regulatory FactorTP63MADS-boxMef2Myocyte-specific Enhancer Factor 2AMEF2BMEF2CMEF2DSerum Response FactorTATA-binding ProteinTATA-binding ProteinTBPL1High-mobility GroupBBX (gene)HMGB1HMGB2HMGB3HMGB4HMGNHMGN1HMGN2HMGN3HMGN4HNF1AHNF1BLymphoid Enhancer-binding Factor 1SOX Gene FamilySOX1SOX2SOX3SOX4SOX5SOX6SOX8SOX9SOX10SOX11SOX12SOX13SOX14SOX15SOX18SOX21Testis Determining FactorStructure Specific Recognition Protein 1TCF3TCF7L2TOXTOX2TOX3TOX4TFCP2CSDA (gene)Y Box Binding Protein 1Core Binding FactorCBFA2T2CBFA2T3RUNX1RUNX2RUNX3RUNX1T1HMGAHMGA1HMGA2HBP1Pocket Protein FamilyRetinoblastoma ProteinRetinoblastoma-like Protein 1Retinoblastoma-like Protein 2Apetala 2Ethylene-responsive Element Binding ProteinApetala 2Ethylene-responsive Element Binding ProteinB3 DomainARID1AARID1BARID2ARID3AARID3BARID4ACatabolite Activator ProteinIFI16IFI35MLL (gene)MLL2MLL3MLLT1MNDANFYANFYBNFYCRho FactorSigma FactorTemplate:Transcription Factor And Coregulator DeficienciesTemplate:Cell Cycle ProteinsTemplate Talk:Cell Cycle ProteinsCell CycleProteinCyclinCyclin ACyclin A1Cyclin A2Cyclin BCyclin B1Cyclin B2Cyclin DCyclin D1Cyclin D2Cyclin D3Cyclin ECyclin E1Cyclin E2Cyclin-dependent KinaseCyclin-dependent Kinase 1Cyclin-dependent Kinase 2Cyclin-dependent Kinase 3Cyclin-dependent Kinase 4Cyclin-dependent Kinase 5Cyclin-dependent Kinase 6Cyclin-dependent Kinase 7Cyclin-dependent Kinase 8Cyclin-dependent Kinase 9Cyclin-dependent Kinase 10CDK-activating KinaseCyclin-dependent Kinase Inhibitor ProteinCell CycleP14arfP16CDKN2BCDKN2CCDKN2DCell CycleP21CDKN1BCyclin-dependent Kinase Inhibitor 1CP53 P63 P73 FamilyP53TP63P73Cdk1Cdc25CDC42Cellular Apoptosis Susceptibility ProteinMaturation Promoting FactorWee1CullinCUL7InterphaseG1 PhaseS PhaseG2 PhaseCell DivisionMitosisPreprophaseProphasePrometaphaseMetaphaseAnaphaseTelophaseCytokinesisCell Cycle CheckpointRestriction PointSpindle CheckpointPostreplication CheckpointApoptosisG0 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