Contents 1 Translation halt 1.1 Biochemistry mechanism 2 See also 3 References

Translation halt[edit] There are a lot of mRNAs that have been transcribed but not translated during dictyate.[6] Shortly before ovulation, the oocyte of interest activates these mRNA strains. Biochemistry mechanism[edit] Translation of mRNA in dictyate is partly explained by molecules binding to sites on the mRNA strain, which results in that initiation factors of translation can not bind to that site. Two such molecules, that impedes initiation factors, are CPEB and maskin, which bind to CPE (cytoplasmic polyadenylation element). When these two molecules remain together, then maskin binds the initiation factor eIF-4E,[6] and thus eIF4E can no longer interact with the other initiation factors[7] and no translation occurs. On the other hand, dissolution of the CPEB/maskin complex leads to eIF-4E binding to the initiation factor eIF-4G,[6] and thus translation starts, which contributes to the end of dictyate and further maturation of the oocyte.

See also[edit] Oogenesis Immature ovum Embryo Zygote

References[edit] ^ Medical Physiology, Boron & Boulpaep, ISBN 1-4160-2328-3, Elsevier Saunders 2005. Updated edition. 1300 pages. ^ a b Thomas, Richard D, ed. (1986). Drinking Water and Health. 6. Washington, D.C.: National Academies Press. p. 35. ISBN 0-309-03687-9.  ^ 'Hormones and Mammalian Egg Maturation', Michael Barresi,, Accessed 15 Apr 08 1613 ^ Titus S, Li F, Stobezki R, Akula K, Unsal E, Jeong K, Dickler M, Robson M, Moy F, Goswami S, Oktay K (2013). "Impairment of BRCA1-related DNA double-strand break repair leads to ovarian aging in mice and humans". Sci Transl Med. 5 (172): 172ra21. doi:10.1126/scitranslmed.3004925. PMC 5130338 . PMID 23408054.  ^ Harris Bernstein, Carol Bernstein and Richard E. Michod (2011). Meiosis as an Evolutionary Adaptation for DNA Repair. Chapter 19 in DNA Repair. Inna Kruman editor. InTech Open Publisher. DOI: 10.5772/25117 ^ a b c - Maskin Is a CPEB-Associated Factor that Transiently Interacts with eIF-4E Barbara Stebbins-Boaz,1 Quiping Cao,1 Cornelia H de Moor,1 Raul Mendez,1 and Joel D Richter1 ^ Lodish 2008, p.351 Retrieved from "" Categories: Developmental biology

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