Contents 1 Function 2 References 3 Further reading 4 External links


Function[edit] CDK3 complements cdc28 mutants of Saccharomyces cerevisiae suggesting that it may be involved in cell cycle control. CDK3 can phosphorylate histone H1 and interacts with an unknown type of cyclin.[4]


References[edit] ^ a b c GRCh38: Ensembl release 89: ENSG00000250506 - Ensembl, May 2017 ^ "Human PubMed Reference:".  ^ Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH (Aug 1992). "A family of human cdc2-related protein kinases". EMBO J. 11 (8): 2909–17. PMC 556772 . PMID 1639063.  ^ a b "Entrez Gene: CDK3 cyclin-dependent kinase 3". 


Further reading[edit] Bullrich F, MacLachlan TK, Sang N, et al. (1995). "Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer". Cancer Res. 55 (6): 1199–205. PMID 7882308.  Gyuris J, Golemis E, Chertkov H, Brent R (1993). "Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2". Cell. 75 (4): 791–803. doi:10.1016/0092-8674(93)90498-F. PMID 8242750.  Sasaguri T, Ishida A, Kosaka C, et al. (1996). "Phorbol ester inhibits the phosphorylation of the retinoblastoma protein without suppressing cyclin D-associated kinase in vascular smooth muscle cells". J. Biol. Chem. 271 (14): 8345–51. doi:10.1074/jbc.271.14.8345. PMID 8626531.  Meikrantz W, Schlegel R (1996). "Suppression of apoptosis by dominant negative mutants of cyclin-dependent protein kinases". J. Biol. Chem. 271 (17): 10205–9. doi:10.1074/jbc.271.17.10205. PMID 8626584.  Hofmann F, Livingston DM (1996). "Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit". Genes Dev. 10 (7): 851–61. doi:10.1101/gad.10.7.851. PMID 8846921.  Lamphere L, Fiore F, Xu X, et al. (1997). "Interaction between Cdc37 and Cdk4 in human cells". Oncogene. 14 (16): 1999–2004. doi:10.1038/sj.onc.1201036. PMID 9150368.  Braun K, Hölzl G, Soucek T, et al. (1998). "Investigation of the cell cycle regulation of cdk3-associated kinase activity and the role of cdk3 in proliferation and transformation". Oncogene. 17 (17): 2259–69. doi:10.1038/sj.onc.1202145. PMID 9811456.  Yamochi T, Semba K, Tsuji K, et al. (2002). "ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3)". Eur. J. Biochem. 268 (23): 6076–82. doi:10.1046/j.0014-2956.2001.02555.x. PMID 11733001.  Sato H, Nishimoto I, Matsuoka M (2002). "ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-abl". Biochim. Biophys. Acta. 1574 (2): 157–63. doi:10.1016/S0167-4781(01)00367-0. PMID 11955625.  Schang LM, Bantly A, Schaffer PA (2002). "Explant-induced reactivation of herpes simplex virus occurs in neurons expressing nuclear cdk2 and cdk4". J. Virol. 76 (15): 7724–35. doi:10.1128/JVI.76.15.7724-7735.2002. PMC 136347 . PMID 12097586.  Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  Ren S, Rollins BJ (2004). "Cyclin C/cdk3 promotes Rb-dependent G0 exit". Cell. 117 (2): 239–51. doi:10.1016/S0092-8674(04)00300-9. PMID 15084261.  Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.  Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.  Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.  Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. Cell. Proteomics. 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257. 


External links[edit] CDK3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) CDK3 human gene location in the UCSC Genome Browser. CDK3 human gene details in the UCSC Genome Browser. v t e Cell cycle proteins Cyclin A (A1, A2) B (B1, B2, B3) D (D1, D2, D3) E (E1, E2) CDK 1 2 3 4 5 6 7 8 9 10 CDK-activating kinase CDK inhibitor INK4a/ARF (p14arf/p16, p15, p18, p19) cip/kip (p21, p27, p57) P53 p63 p73 family p53 p63 p73 Other Cdc2 Cdc25 Cdc42 Cellular apoptosis susceptibility protein E2F Maturation promoting factor Wee Cullin (CUL7) Phases and checkpoints Interphase G1 phase S phase G2 phase M phase Mitosis (Preprophase Prophase Prometaphase Metaphase Anaphase Telophase) Cytokinesis Cell cycle checkpoints Restriction point Spindle checkpoint Postreplication checkpoint Other cellular phases Apoptosis G0 phase Meiosis v t e Kinases: Serine/threonine-specific protein kinases (EC 2.7.11-12) Serine/threonine-specific protein kinases (EC 2.7.11.1-EC 2.7.11.20) Non-specific serine/threonine protein kinases (EC 2.7.11.1) LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated Mammalian target of rapamycin EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 Dephospho-(reductase kinase) kinase (EC 2.7.11.3) AMP-activated protein kinase α PRKAA1 PRKAA2 β PRKAB1 PRKAB2 γ PRKAG1 PRKAG2 PRKAG3 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4) BCKDK BCKDHA BCKDHB (isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5) IDH2 IDH3A IDH3B IDH3G (tyrosine 3-monooxygenase) kinase (EC 2.7.11.6) STK4 Myosin-heavy-chain kinase (EC 2.7.11.7) Aurora kinase Aurora A kinase Aurora B kinase Fas-activated serine/threonine kinase (EC 2.7.11.8) FASTK STK10 Goodpasture-antigen-binding protein kinase (EC 2.7.11.9) - IκB kinase (EC 2.7.11.10) CHUK IKK2 TBK1 IKBKE IKBKG IKBKAP cAMP-dependent protein kinase (EC 2.7.11.11) Protein kinase A PRKACG PRKACB PRKACA PRKY cGMP-dependent protein kinase (EC 2.7.11.12) Protein kinase G PRKG1 Protein kinase C (EC 2.7.11.13) Protein kinase C Protein kinase Cζ PKC alpha PRKCB1 PRKCD PRKCE PRKCH PRKCG PRKCI PRKCQ Protein kinase N1 PKN2 PKN3 Rhodopsin kinase (EC 2.7.11.14) Rhodopsin kinase Beta adrenergic receptor kinase (EC 2.7.11.15) Beta adrenergic receptor kinase Beta adrenergic receptor kinase-2 G-protein coupled receptor kinases (EC 2.7.11.16) GRK4 GRK5 GRK6 Ca2+/calmodulin-dependent (EC 2.7.11.17) BRSK2 CAMK1 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 MLCK CASK CHEK1 CHEK2 DAPK1 DAPK2 DAPK3 STK11 MAPKAPK2 MAPKAPK3 MAPKAPK5 MARK1 MARK2 MARK3 MARK4 MELK MKNK1 MKNK2 NUAK1 NUAK2 OBSCN PASK PHKG1 PHKG2 PIM1 PIM2 PKD1 PRKD2 PRKD3 PSKH1 SNF1LK2 KIAA0999 STK40 SNF1LK SNRK SPEG TSSK2 Kalirin TRIB1 TRIB2 TRIB3 TRIO Titin DCLK1 Myosin light-chain kinase (EC 2.7.11.18) MYLK MYLK2 MYLK3 MYLK4 Phosphorylase kinase (EC 2.7.11.19) PHKA1 PHKA2 PHKB PHKG1 PHKG2 Elongation factor 2 kinase (EC 2.7.11.20) EEF2K STK19 Polo kinase (EC 2.7.11.21) PLK1 PLK2 PLK3 PLK4 Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30) Polo kinase (EC 2.7.11.21) PLK1 PLK2 PLK3 PLK4 Cyclin-dependent kinase (EC 2.7.11.22) CDK1 CDK2 CDKL2 CDK3 CDK4 CDK5 CDKL5 CDK6 CDK7 CDK8 CDK9 CDK10 CDK12 CDC2L5 PCTK1 PCTK2 PCTK3 PFTK1 CDC2L1 (RNA-polymerase)-subunit kinase (EC 2.7.11.23) RPS6KA5 RPS6KA4 P70S6 kinase P70-S6 Kinase 1 RPS6KB2 RPS6KA2 RPS6KA3 RPS6KA1 RPS6KC1 Mitogen-activated protein kinase (EC 2.7.11.24) Extracellular signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14 MAP3K (EC 2.7.11.25) MAP kinase kinase kinases MAP3K1 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K6 MAP3K7 MAP3K8 RAFs ARAF BRAF KSR1 KSR2 MLKs MAP3K12 MAP3K13 MAP3K9 MAP3K10 MAP3K11 MAP3K7 ZAK CDC7 MAP3K14 Tau-protein kinase (EC 2.7.11.26) TPK1 TTK GSK-3 (acetyl-CoA carboxylase) kinase (EC 2.7.11.27) - Tropomyosin kinase (EC 2.7.11.28) - Low-density-lipoprotein receptor kinase (EC 2.7.11.29) - Receptor protein serine/threonine kinase (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Dual-specificity kinases (EC 2.7.12) MAP2K MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7 v t e Enzymes Activity Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Regulation Allosteric regulation Cooperativity Enzyme inhibitor Classification EC number Enzyme superfamily Enzyme family List of enzymes Kinetics Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics Types EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) Molecular and Cellular Biology portal This EC 2.7 enzyme-related article is a stub. You can help Wikipedia by expanding it. v t e Retrieved from "https://en.wikipedia.org/w/index.php?title=Cyclin-dependent_kinase_3&oldid=798050123" Categories: Genes on human chromosome 17Cell cycleProteinsEC 2.7.11Hidden categories: All stub articlesEC 2.7 stubs


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Cyclin-dependent_kinase_3 - Photos and All Basic Informations

Cyclin-dependent_kinase_3 More Links

Dorset/Kawagama Lake (South) Water AerodromeProtein Data BankGene NomenclatureHomoloGeneGeneCardsChromosome 17 (human)ChromosomeChromosome 17 (human)Chromosome 17 (human)Genomic Location For CDK3Genomic Location For CDK3Locus (genetics)Base PairBase PairGene ExpressionGene OntologyEntrezEnsemblUniProtPubMedWikidataEnzymeGeneSaccharomyces CerevisiaeCell CyclePhosphorylateHistone H1CyclinEnsembl Genome Database ProjectPubMed CentralPubMed IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed CentralPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierMedical Subject HeadingsUCSC Genome BrowserUCSC Genome BrowserTemplate:Cell Cycle ProteinsTemplate Talk:Cell Cycle ProteinsCell CycleProteinCyclinCyclin ACyclin A1Cyclin A2Cyclin BCyclin B1Cyclin B2Cyclin DCyclin D1Cyclin D2Cyclin D3Cyclin ECyclin E1Cyclin E2Cyclin-dependent KinaseCyclin-dependent Kinase 1Cyclin-dependent Kinase 2Cyclin-dependent Kinase 4Cyclin-dependent Kinase 5Cyclin-dependent Kinase 6Cyclin-dependent Kinase 7Cyclin-dependent Kinase 8Cyclin-dependent Kinase 9Cyclin-dependent Kinase 10CDK-activating KinaseCyclin-dependent Kinase Inhibitor ProteinCell CycleP14arfP16CDKN2BCDKN2CCDKN2DCell CycleP21CDKN1BCyclin-dependent Kinase Inhibitor 1CP53 P63 P73 FamilyP53TP63P73Cdk1Cdc25CDC42Cellular Apoptosis Susceptibility ProteinE2FMaturation Promoting FactorWee1CullinCUL7InterphaseG1 PhaseS PhaseG2 PhaseCell DivisionMitosisPreprophaseProphasePrometaphaseMetaphaseAnaphaseTelophaseCytokinesisCell Cycle CheckpointRestriction PointSpindle CheckpointPostreplication CheckpointApoptosisG0 PhaseMeiosisTemplate:Serine/threonine-specific Protein KinasesTemplate Talk:Serine/threonine-specific Protein KinasesKinaseSerine/threonine-specific Protein KinaseEnzyme Commission NumberSerine/threonine-specific Protein KinaseNon-specific Serine/threonine Protein KinaseLATS1LATS2MAST1MAST2STK38STK38LCIT (gene)ROCK1SGKSGK2SGK3AKTAKT1AKT2AKT3Ataxia Telangiectasia MutatedMammalian Target Of RapamycinEIF-2 KinaseProtein Kinase REIF2AK1EIF2AK3EIF2AK4Wee1Wee1-like Protein KinasePyruvate Dehydrogenase KinasePyruvate Dehydrogenase Lipoamide Kinase Isozyme 1PDK2PDK3Dephospho-(reductase Kinase) KinaseAMP-activated Protein KinaseProtein Kinase, AMP-activated, Alpha 1PRKAA2PRKAB1PRKAB2PRKAG1PRKAG2PRKAG33-methyl-2-oxobutanoate Dehydrogenase (acetyl-transferring) KinaseBCKDKBCKDHABCKDHB(isocitrate Dehydrogenase (NADP+)) KinaseIDH2IDH3AIDH3BIDH3G(tyrosine 3-monooxygenase) KinaseSTK4Myosin-heavy-chain KinaseAurora KinaseAurora A KinaseAurora B KinaseFas-activated Serine/threonine KinaseFASTKSTK10Goodpasture-antigen-binding Protein KinaseIκB KinaseCHUKIKK2TANK-binding Kinase 1IKBKEIKBKGIKBKAPProtein Kinase AProtein Kinase APRKACGPRKACBPRKACAPRKYCGMP-dependent Protein KinaseCGMP-dependent Protein KinasePRKG1Protein Kinase CProtein Kinase CProtein Kinase C Zeta TypePKC AlphaPRKCB1PRKCDPRKCEPRKCHPRKCGPRKCIPRKCQProtein Kinase N1PKN2PKN3 (gene)Rhodopsin KinaseRhodopsin KinaseBeta Adrenergic Receptor KinaseBeta Adrenergic Receptor KinaseBeta Adrenergic Receptor Kinase-2G Protein-coupled Receptor KinaseGRK4GRK5GRK6Ca2+/calmodulin-dependent Protein KinaseBRSK2CAMK1CAMK2ACAMK2BCAMK2DCAMK2GCAMK4Myosin Light-chain KinaseCASKCHEK1CHEK2DAPK1DAPK2DAPK3STK11MAPKAPK2MAPKAPK3MAPKAPK5MARK1MARK2MARK3MARK4MELKMKNK1MKNK2NUAK1NUAK2OBSCNPASKPHKG1PHKG2PIM1PIM2 (gene)Protein Kinase D1PRKD2PRKD3PSKH1SNF1LK2KIAA0999STK40SNF1LKSNRKSPEGTSSK2KalirinTRIB1TRIB2TRIB3TRIO (gene)TitinDCLK1Myosin Light-chain KinaseMYLKMYLK2MYLK3MYLK4Phosphorylase KinasePhosphorylase Kinase, Alpha 1PHKA2PHKBPHKG1PHKG2Elongation Factor 2 KinaseEEF2KSTK19Polo KinasePLK1PLK2PLK3PLK4Serine/threonine-specific Protein KinasePolo KinasePLK1PLK2PLK3PLK4Cyclin-dependent KinaseCdk1Cyclin-dependent Kinase 2CDKL2Cyclin-dependent Kinase 4Cyclin-dependent Kinase 5CDKL5Cyclin-dependent Kinase 6Cyclin-dependent Kinase 7Cyclin-dependent Kinase 8CDK9Cyclin-dependent Kinase 10CDK12CDC2L5PCTK1PCTK2PCTK3PFTK1CDC2L1(RNA-polymerase)-subunit KinaseRPS6KA5RPS6KA4P70S6 KinaseP70-S6 Kinase 1RPS6KB2RPS6KA2RPS6KA3RPS6KA1RPS6KC1Mitogen-activated Protein KinaseExtracellular Signal-regulated KinasesMAPK1MAPK3MAPK4MAPK6MAPK7MAPK12MAPK15C-Jun N-terminal KinasesMAPK8Mitogen-activated Protein Kinase 9MAPK10P38 Mitogen-activated Protein KinasesMAPK11MAPK13MAPK14MAP Kinase Kinase KinaseMAP Kinase Kinase KinaseMAP3K1MAP3K2MAP3K3MAP3K4ASK1MAP3K7MAP3K8C-RafARAFBRAF (gene)KSR1KSR2MAP3K12MAP3K13MAP3K9MAP3K10MAP3K11MAP3K7ZAKCell Division Cycle 7-related Protein KinaseMAP3K14Tau-protein KinaseTPK1TTK (gene)GSK-3(acetyl-CoA Carboxylase) KinaseTropomyosin KinaseLow-density-lipoprotein Receptor KinaseReceptor Protein Serine/threonine KinaseBone Morphogenetic Protein ReceptorsBone Morphogenetic Protein Receptor, Type 1BMPR1ABMPR1BBMPR2ACVR1ACVR1BACVR1CACVR2AACVR2BACVRL1Anti-Müllerian Hormone ReceptorDual-specificity KinaseMitogen-activated Protein Kinase KinaseMAP2K1MAP2K2MAP2K3MAP2K4MAP2K5MAP2K6MAP2K7Template:EnzymesTemplate Talk:EnzymesEnzymeActive SiteBinding SiteCatalytic TriadOxyanion HoleEnzyme PromiscuityCatalytically Perfect EnzymeCoenzymeCofactor (biochemistry)Enzyme CatalysisAllosteric RegulationCooperativityEnzyme InhibitorEnzyme Commission NumberEnzyme SuperfamilyEnzyme FamilyList Of EnzymesEnzyme KineticsEadie–Hofstee DiagramHanes–Woolf PlotLineweaver–Burk PlotMichaelis–Menten KineticsOxidoreductaseList Of EC Numbers (EC 1)TransferaseList Of EC Numbers (EC 2)HydrolaseList Of EC Numbers (EC 3)LyaseList Of EC Numbers (EC 4)IsomeraseList Of EC Numbers (EC 5)LigaseList Of EC Numbers (EC 6)Portal:Molecular And Cellular BiologyEC 2.7EnzymeWikipedia:StubTemplate:2.7-enzyme-stubTemplate Talk:2.7-enzyme-stubHelp:CategoryCategory:Genes On Human Chromosome 17Category:Cell CycleCategory:ProteinsCategory:EC 2.7.11Category:All Stub ArticlesCategory:EC 2.7 StubsDiscussion About Edits From This IP Address [n]A List Of Edits Made From This IP Address [y]View The Content Page [c]Discussion About The Content Page [t]Edit This Page [e]Visit The Main Page [z]Guides To Browsing WikipediaFeatured Content – The Best Of WikipediaFind Background Information On Current EventsLoad A Random Article [x]Guidance On How To Use And Edit WikipediaFind Out About WikipediaAbout The Project, What You Can Do, Where To Find ThingsA List Of Recent Changes In The Wiki [r]List Of All English 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