Contents 1 Development and structure 2 Function 2.1 When egg is not fertilized 2.2 When egg is fertilized 2.3 Content of carotenoids 3 In animals 4 Additional images 5 Pathology 6 References 7 Biography 8 External links

Development and structure[edit] The corpus luteum develops from an ovarian follicle during the luteal phase of the menstrual cycle or oestrous cycle, following the release of a secondary oocyte from the follicle during ovulation. The follicle first forms a corpus hemorrhagicum before it becomes a corpus luteum, but the term refers to the visible collection of blood, left after rupture of the follicle, that secretes progesterone. While the oocyte (later the zygote if fertilization occurs) traverses the Fallopian tube into the uterus, the corpus luteum remains in the ovary. The corpus luteum is typically very large relative to the size of the ovary; in humans, the size of the structure ranges from under 2 cm to 5 cm in diameter.[4] Its cells develop from the follicular cells surrounding the ovarian follicle.[5] The follicular theca cells luteinize into small luteal cells (thecal-lutein cells) and follicular granulosa cells luteinize into large luteal cells (granulosal-lutein cells) forming the corpus luteum. Progesterone is synthesized from cholesterol by both the large and small luteal cells upon luteal maturation. Cholesterol-LDL complexes bind to receptors on the plasma membrane of luteal cells and are internalized. Cholesterol is released and stored within the cell as cholesterol ester. LDL is recycled for further cholesterol transport. Large luteal cells produce more progesterone due to uninhibited/basal levels of protein kinase A (PKA) activity within the cell. Small luteal cells have LH receptors that regulate PKA activity within the cell. PKA actively phosphorylates steroidogenic acute regulatory protein (StAR) and translocator protein to transport cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane.[6] The development of the corpus luteum is accompanied by an increase in the level of the steroidogenic enzyme P450scc that converts cholesterol to pregnenolone in the mitochondria.[7] Pregnenolone is then converted to progesterone that is secreted out of the cell and into the blood stream. During the bovine estrous cycle, plasma levels of progesterone increase in parallel to the levels of P450scc and its electron donor adrenodoxin, indicating that progesterone secretion is a result of enhanced expression of P450scc in the corpus luteum.[7] The mitochondrial P450 system electron transport chain including adrenodoxin reductase and adrenodoxin has been shown to leak electrons leading to the formation of superoxide radical.[8][9] Apparently to cope with the radicals produced by this system and by enhanced mitochondrial metabolism, the levels of antioxidant enzymes catalase and superoxide dismutase also increase in parallel with the enhanced steroidogenesis in the corpus luteum.[7] Follicular structure Luteal structure Secretion Theca cells Theca lutein cells androgens,[10] progesterone[10] Granulosa cells Granulosa lutein cells progesterone,[5] estrogen(majority),[5] and inhibin A[5][10] Steroidogenesis, with progesterone in yellow field at upper center.[11] The androgens are shown in blue field, and aromatase at lower center - the enzyme present in granulosa lutein cells that convert androgens into estrogens (shown in pink triangle). Like the previous theca cells, the theca lutein cells lack the aromatase enzyme that is necessary to produce estrogen, so they can only perform steroidogenesis until formation of androgens. The granulosa lutein cells do have aromatase, and use it to produce estrogens, using the androgens previously synthesized by the theca lutein cells, as the granulosa lutein cells in themselves do not have the 17α-hydroxylase or 17,20 lyase to produce androgens.[5] Once the corpus luteum regresses the remnant is known as corpus albicans.[12]

Function[edit] The corpus luteum is essential for establishing and maintaining pregnancy in females. The corpus luteum secretes progesterone, which is a steroid hormone responsible for the decidualization of the endometrium (its development) and maintenance, respectively. It also produces relaxin, a hormone responsible for softening of the pubic symphysis which helps in parturition. When egg is not fertilized[edit] If the egg is not fertilized, the corpus luteum stops secreting progesterone and decays (after approximately 10 days in humans). It then degenerates into a corpus albicans, which is a mass of fibrous scar tissue. The uterine lining (endometrium) is expelled through the vagina (in mammals that go through a menstrual cycle). In an estrous cycle, the lining degenerates back to normal size. When egg is fertilized[edit] Vaginal ultrasound showing a corpus luteum in a pregnant woman, with a fluid-filled cavity in its center. If the egg is fertilized and implantation occurs, the syncytiotrophoblast (derived from trophoblast) cells of the blastocyst secrete the hormone human chorionic gonadotropin (hCG, or a similar hormone in other species) by day 9 post-fertilization. Human chorionic gonadotropin signals the corpus luteum to continue progesterone secretion, thereby maintaining the thick lining (endometrium) of the uterus and providing an area rich in blood vessels in which the zygote(s) can develop. From this point on, the corpus luteum is called the corpus luteum graviditatis. The introduction of prostaglandins at this point causes the degeneration of the corpus luteum and the abortion of the fetus. However, in placental animals such as humans, the placenta eventually takes over progesterone production and the corpus luteum degrades into a corpus albicans without embryo/fetus loss. Luteal support refers to the administration of medication (generally progestins) for the purpose of increasing the success of implantation and early embryogenesis, thereby complementing the function of the corpus luteum. Content of carotenoids[edit] The yellow color and name of the corpus luteum, like that of the macula lutea of the retina, is due to its concentration of certain carotenoids, especially lutein. In 1968, a report indicated that beta-carotene was synthesized in laboratory conditions in slices of corpus luteum from cows. However, attempts have been made to replicate these findings, but have not succeeded. The idea is not presently accepted by the scientific community.[13] Rather, the corpus luteum concentrates carotenoids from the diet of the mammal.

In animals[edit] Similar structures and functions of the corpus luteum exist in some reptiles.[14] Dairy cattle also follow a similar cycle.[15]

Additional images[edit] Order of changes in ovary Human ovary with fully developed corpus luteum Luteinized follicular cyst. H&E stain.

Pathology[edit] Corpus Luteum cyst: hemorrhage into persistent corpus luteum. Commonly regresses spontaneously.

References[edit] ^ ^ Inquiry Into Biology (Textbook). McGraw-Hill Ryerson. 2007. p. 497. ISBN 978-0-07-096052-7.  ^ Karch, p. 657. ^ Vegetti W, Alagna F (2006). "FSH and follucogenesis: from physiology to ovarian stimulation". Reproductive biomedicine Online. Retrieved 2009-05-26.  ^ a b c d e Boron, p. 1300. ^ Niswender GD (March 2002). "Molecular control of luteal secretion of progesterone". Reproduction. 123 (3): 333–9. doi:10.1530/rep.0.1230333. PMID 11882010.  ^ a b c Rapoport R, Sklan D, Wolfenson D, Shaham-Albalancy A, Hanukoglu I (March 1998). "Antioxidant capacity is correlated with steroidogenic status of the corpus luteum during the bovine estrous cycle". Biochim. Biophys. Acta. 1380 (1): 133–40. doi:10.1016/S0304-4165(97)00136-0. PMID 9545562.  ^ Hanukoglu I, Rapoport R, Weiner L, Sklan D (September 1993). "Electron leakage from the mitochondrial NADPH-adrenodoxin reductase-adrenodoxin-P450scc (cholesterol side chain cleavage) system". Arch. Biochem. Biophys. 305 (2): 489–98. doi:10.1006/abbi.1993.1452. PMID 8396893.  ^ Rapoport R, Sklan D, Hanukoglu I (March 1995). "Electron leakage from the adrenal cortex mitochondrial P450scc and P450c11 systems: NADPH and steroid dependence". Arch. Biochem. Biophys. 317 (2): 412–6. doi:10.1006/abbi.1995.1182. PMID 7893157.  ^ a b c The IUPS Physiome Project --> Female Reproductive System – Cells Retrieved on Nov 9, 2009 ^ Häggström, Mikael; Richfield, David (2014). "Diagram of the pathways of human steroidogenesis". WikiJournal of Medicine. 1 (1). doi:10.15347/wjm/2014.005. ISSN 2002-4436.  ^ Marieb, Elaine (2013). Anatomy & physiology. Benjamin-Cummings. p. 915. ISBN 9780321887603.  ^ Brian Davis. Carotenoid metabolism as a preparation for function. Pure and Applied Chemistry, Vol. 63, No. 1, pp. 131–140, 1991. available online. Accessed April 30, 2010. ^ Trauth, Stanley E. (1978). "Ovarian Cycle of Crotaphytus collaris (Reptilia, Lacertilia, Iguanidae) from Arkansas with Emphasis on Corpora Albicantia, Follicular Atresia, and Reproductive Potential". Journal of Herpetology. 12 (4): 461. doi:10.2307/1563350. ISSN 0022-1511. JSTOR 1563350.  ^ Dairy cattle fertility & sterility. Hoard's Dairyman. Fort Atkinson, Wis: W.D. Hoard & Sons. 1996. ISBN 978-0932147271. 

Biography[edit] Karch, Amy (2017). Focus on nursing pharmacology. Philadelphia: Wolters Kluwer. ISBN 9781496318213.  Boron, Walter (2005). Medical physiology : a cellular and molecular approach. Philadelphia, Penns: Elsevier Saunders. ISBN 1-4160-2328-3. 

External links[edit] Histology image: 18201loa – Histology Learning System at Boston University Anatomy photo:43:05-0106 at the SUNY Downstate Medical Center – "The Female Pelvis: The Ovary" CT of the abdomen showing a ruptured hemorrhagic copus luteal cyst v t e Female reproductive system Internal Adnexa Ovaries Follicles corpus hemorrhagicum luteum albicans Theca of follicle externa interna Follicular antrum Follicular fluid Corona radiata Zona pellucida Membrana granulosa Perivitelline space Other Germinal epithelium Tunica albuginea cortex Cumulus oophorus Stroma Medulla Fallopian tubes Isthmus Ampulla Infundibulum Fimbria Ostium Ligaments Ovarian ligament Suspensory ligament Wolffian vestiges Gartner's duct Epoophoron Vesicular appendages of epoophoron Paroophoron Uterus Regions Body Uterine cavity Fundus Cervix External orifice Cervical canal Internal orifice Supravaginal portion Vaginal portion Uterine horns Layers Endometrium epithelium Myometrium Perimetrium Parametrium Ligaments Round ligament Broad ligament Cardinal ligament Uterosacral ligament Pubocervical ligament General Uterine glands Vagina Fossa of vestibule of vagina Vaginal fornix Hymen External Vulva Labia Mons pubis Labia majora Anterior commissure Posterior commissure Pudendal cleft Labia minora Frenulum of labia minora Frenulum of clitoris Vulval vestibule Interlabial sulci Bulb of vestibule Vaginal orifice vestibular glands/ducts Bartholin's glands/Bartholin's ducts Skene's glands/Skene's ducts Clitoris Crus of clitoris Corpus cavernosum Clitoral glans Hood Urethra Urethral crest Other G-spot Urethral sponge Perineal sponge Retrieved from "" Categories: HistologyMammal female reproductive systemPelvisHuman female endocrine systemTheriogenologyHidden categories: Medicine infobox template using GraySubject or GrayPageMedicine infobox template using Dorlands parameterAll articles with unsourced statementsArticles with unsourced statements from March 2017

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Corpus_luteum - Photos and All Basic Informations

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Stroma Of OvaryLatinElsevierTerminologia AnatomicaFoundational Model Of AnatomyAnatomical TerminologyLatinEndocrineOvariesProgesteroneEstradiolInhibin ACarotenoidLuteinEstrogenGonadotropin-releasing HormoneLuteinizing HormoneFollicle-stimulating HormoneMenstrual CycleWikipedia:Citation NeededOvarian FollicleLuteal PhaseMenstrual CycleOestrous CycleOvulationCorpus HemorrhagicumOocyteZygoteFallopian TubeUterusOvaryTheca CellGranulosa CellLow-density LipoproteinProtein Kinase ASteroidogenic Acute Regulatory ProteinTranslocator ProteinP450sccPregnenoloneAdrenodoxin ReductaseAdrenodoxinTheca Of FollicleAndrogenProgesteroneGranulosa CellEstrogenInhibin AEnlargeSteroidogenesisProgesteroneAndrogenAromataseEstrogenAromataseSteroidogenesisAndrogen17α-hydroxylase17,20 LyaseCorpus AlbicansProgesteroneSteroid HormoneDecidualizationEndometriumRelaxinPubic SymphysisCorpus AlbicansScarMenstrual CycleEstrous CycleEnlargeVaginal UltrasoundImplantation (human Embryo)TrophoblastBlastocystHuman Chorionic GonadotropinBlood VesselZygoteProstaglandinAbortionFetusPlacentaCorpus AlbicansLuteal SupportProgestinImplantation (human Embryo)Human EmbryogenesisMacula LuteaCarotenoidLuteinH&E StainCorpus Luteum CystInternational Standard Book NumberSpecial:BookSources/978-0-07-096052-7Digital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierInternational Standard Serial NumberInternational Standard Book NumberSpecial:BookSources/9780321887603Digital Object IdentifierInternational Standard Serial NumberJSTORInternational Standard Book NumberSpecial:BookSources/978-0932147271International Standard Book NumberSpecial:BookSources/9781496318213International Standard Book NumberSpecial:BookSources/1-4160-2328-3Template:Female Reproductive SystemTemplate Talk:Female Reproductive SystemFemale Reproductive SystemSex OrganAdnexa Of UterusOvaryOvarian FollicleCorpus HemorrhagicumCorpus AlbicansTheca Of FollicleTheca ExternaTheca InternaFollicular AntrumFollicular FluidCorona Radiata (embryology)Zona PellucidaMembrana GranulosaPerivitelline SpaceGerminal Epithelium (female)Tunica Albuginea (ovaries)Cumulus OophorusStroma Of OvaryMedulla Of OvaryFallopian TubeIsthmus Of Uterine TubeAmpulla Of Uterine TubeInfundibulum Of Uterine TubeFimbriae Of Uterine TubeOstium Of Uterine TubeLigamentOvarian LigamentSuspensory Ligament Of OvaryMesonephric DuctGartner's DuctEpoophoronVesicular Appendages Of EpoophoronParoophoronUterusUterusUterine CavityFundus (uterus)CervixExternal Orifice Of The UterusCervical CanalInternal Orifice Of The UterusSupravaginal Portion Of CervixVaginal Portion Of CervixUterine HornsUterusEndometriumUterine EpitheliumMyometriumPerimetriumParametriumUterusRound Ligament Of UterusBroad Ligament Of The UterusCardinal LigamentUterosacral LigamentPubocervical LigamentUterine GlandVaginaFossa Of Vestibule Of VaginaVaginal FornixHymenSex OrganVulvaLabiaMons PubisLabia MajoraAnterior Commissure Of Labia MajoraPosterior Commissure Of Labia MajoraPudendal CleftLabia MinoraFrenulum Of Labia MinoraClitorisVulval VestibuleInterlabial SulciBulb Of VestibuleVaginaBartholin's GlandSkene's GlandClitorisCrus Of ClitorisCorpus Cavernosum Of ClitorisClitorisClitoral HoodUrethraUrethral CrestG-spotUrethral SpongePerineal SpongeHelp:CategoryCategory:HistologyCategory:Mammal Female Reproductive SystemCategory:PelvisCategory:Human Female Endocrine SystemCategory:TheriogenologyCategory:Medicine Infobox Template Using GraySubject Or GrayPageCategory:Medicine Infobox Template Using Dorlands ParameterCategory:All Articles With Unsourced StatementsCategory:Articles With Unsourced Statements From March 2017Discussion About Edits From This IP Address [n]A List Of Edits Made From This IP Address [y]View The Content Page [c]Discussion About The Content Page [t]Edit This Page [e]Visit The Main Page [z]Guides To Browsing WikipediaFeatured Content – The Best Of WikipediaFind Background Information On Current EventsLoad A Random Article [x]Guidance On How To Use And Edit WikipediaFind Out About WikipediaAbout The Project, What You Can Do, Where To Find ThingsA List Of Recent Changes In The Wiki [r]List Of All English Wikipedia Pages Containing Links To This Page [j]Recent Changes In Pages Linked From This Page [k]Upload Files [u]A List Of All Special Pages [q]Wikipedia:AboutWikipedia:General Disclaimer

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