Worked example[edit] Drosophila females of genotype a+a b+b c+c were crossed with males of genotype aa bb cc. This led to 1000 progeny of the following phenotypes: a+b+c+: 244 (parental genotype, shows no recombination) a+b+c: 81 (recombinant between B and C) a+bc+: 23 (double recombinant) a+bc: 152 (recombinant between A and B) ab+c+: 148 (recombinant between A and B) ab+c: 27 (double recombinant) abc+: 89 (recombinant between B and C) abc: 236 (parental genotype, shows no recombination) From these numbers it is clear that the b+/b locus lies between the a+/a locus and the c+/c locus. There are 23 + 152 + 148 + 27 = 350 progeny showing recombination between genes A and B. And there are 81 + 23 + 27 + 89 = 220 progeny showing recombination between genes B and C. Thus the expected rate of double recombination is (350 / 1000) * (220 / 1000) = 0.077, or 77 per 1000. However, there are actually only 23 + 27 = 50 double recombinants. The coefficient of coincidence is therefore 50 / 77 = 0.65. Interference is 1 − 0.65 = 0.35.

References[edit] ^ a b c Griffiths AJF, Wessler SR, Lewontin RC, Carroll SB (2008) Introduction to Genetic Analysis. New York: W. H. Freeman and Company. Retrieved from "" Categories: Genetics

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